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- A highly enantioselective intramolecular 1,3-dipolar cycloaddition yields novel pseudo-natural product inhibitors of the Hedgehog signalling pathway. Jie Liu, Ruirui Zhang, Shubhadip Mallick, Sohan Patil, Chantal Wientjens, Jana Flegel, Anna Krupp, Carsten Strohmann, Corentin Grassin, Christian Merten, Axel Pahl, Michael Grigalunas, Herbert Waldmann
, Chem. Sci.
, 2023
, 14
, 7936
- Activation barriers in Class F G protein-coupled receptors revealed by umbrella sampling simulations. Mark Agostino, Sebastian Ă–ther-Gee Pohl
, Org. Biomol. Chem.
, 2020
, 18
, 9816
- Synthesis and evaluation of novel N-3-benzimidazolephenylbisamide derivatives for antiproliferative and Hedgehog pathway inhibitory activity. Chiyu Sun, Yangsheng Li, Ailong Shi, Jingzhou Zhang, Yafei Li, Mingming Zhao, Lijuan Zhang, Huachuan Zheng, Ying Meng, Huaiwei Ding, Hongrui Song
, Med. Chem. Commun.
, 2015
, 6
, 1137
- Synthesis of 2-methoxybenzamide derivatives and evaluation of their hedgehog signaling pathway inhibition. Chiyu Sun, Dajun Zhang, Tian Luan, Youbing Wang, Wenhu Zhang, Lin Lin, Meihua Jiang, Ziqian Hao, Ying Wang
, RSC Adv.
, 2021
, 11
, 22820
- Hedgehog signalling pathway inhibitors as cancer suppressing agents. Trieu N. Trinh, Eileen A. McLaughlin, Christopher P. Gordon, Adam McCluskey
, Med. Chem. Commun.
, 2014
, 5
, 117
- Design, synthesis and evaluation of novel tetrahydrothieno[3,2-c]pyridine derivatives as potent smoothened antagonists. Xiaofeng Chen, Chiyu Sun, Jingzhou Zhang, Huaiwei Ding, Hongrui Song
, Med. Chem. Commun.
, 2016
, 7
, 960
- Progress on cocrystallization of poorly soluble NME's in the last decade. Parag Roy, Animesh Ghosh
, CrystEngComm
, 2020
, 22
, 6958
- Visible light photocatalysis in the late-stage functionalization of pharmaceutically relevant compounds. Rolando Cannalire, Sveva Pelliccia, Luca Sancineto, Ettore Novellino, Gian Cesare Tron, Mariateresa Giustiniano
, Chem. Soc. Rev.
, 2021
, 50
, 766
- I only have eye for ewe: the discovery of cyclopamine and development of Hedgehog pathway-targeting drugs. James K. Chen
, Nat. Prod. Rep.
, 2016
, 33
, 595
- Challenges and opportunities on sustainable electrochemical transformations: application towards the synthesis of pharmaceuticals and precursors of drug-like molecules. Adrija Ghosh, Vishal Kumar Parida, Debasis Banerjee
, Green Chem.
, 2024