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- Exploring the binding properties of agonists interacting with human TGR5 using structural modeling, molecular docking and dynamics simulations. Thangaraj Sindhu, Pappu Srinivasan
, RSC Adv.
, 2015
, 5
, 14202
- Oleanolic acid alleviate intestinal inflammation by inhibiting Takeda G-coupled protein receptor (TGR) 5 mediated cell apoptosis. Zhenya Zhai, Yichun Liu, Kaimin Niu, Weirong Zeng, Ruxia Wang, Xiongchang Guo, Chong Lin, Linfang Hu
, Food Funct.
, 2024
, 15
, 1963
- Identification of potential dual agonists of FXR and TGR5 using e-pharmacophore based virtual screening. Thangaraj Sindhu, Pappu Srinivasan
, Mol. BioSyst.
, 2015
, 11
, 1305
- Dietary polyphenols maintain homeostasis via regulating bile acid metabolism: a review of possible mechanisms. Yongyong Liu, Kai Huang, Yu Zhang, Hongwei Cao, Xiao Guan
, Food Funct.
, 2023
, 14
, 9486
- Taurocholic acid ameliorates hypertension through the activation of TGR5 in the hypothalamic paraventricular nucleus. Ying Li, Ya-Nan Gao, Ying-Bao Zhu, Wen-Fang Lu, Jia-Yue Yu, Yuan-Yuan Dong, Meng-Yue Xu, Bo Peng, Jun-Zhe Wu, Qing Su, Juan Bai, Xiao-Lian Shi, Yu-Ming Kang, Hong-Bao Li, Meng-Lu Xu
, Food Funct.
, 2024
- Ligand-based pharmacophore modeling, virtual screening and biological evaluation to identify novel TGR5 agonists. Shizhen Zhao, Xinping Li, Wenjing Peng, Le Wang, Wenling Ye, Yang Zhao, Wenbo Yin, Wei-Dong Chen, Weiguo Li, Yan-Dong Wang
, RSC Adv.
, 2021
, 11
, 9403
- Folic acid supplementation prevents high body fat-induced bone loss through TGR5 signaling pathways. Yaxi Zhang, Jieqiong Wei, Xiangling Feng, Qian Lin, Jing Deng, Yuehan Yuan, Min Li, Bingfang Zhai, Jihua Chen
, Food Funct.
, 2024
, 15
, 4193
- Protective effects of taurocholic acid on excessive hepatic lipid accumulation via regulation of bile acid metabolism in grouper. Jia Xu, Shiwei Xie, Shuyan Chi, Shuang Zhang, Junming Cao, Beiping Tan
, Food Funct.
, 2022
, 13
, 3050
- Synthesis of 12β-methyl-18-nor-avicholic acid analogues as potential TGR5 agonists. Elizabeth M. Ure, Lawrence D. Harris, Scott A. Cameron, Alex Weymouth-Wilson, Richard H. Furneaux, Janet L. Pitman, Simon. F. Hinkley, Andreas Luxenburger
, Org. Biomol. Chem.
, 2022
, 20
, 3511
- Design, synthesis and evaluation of 3-phenoxypyrazine-2-carboxamide derivatives as potent TGR5 agonists. Shizhen Zhao, Le Wang, Jie Wang, Chenwei Wang, Shaowei Zheng, Yajie Fu, Yunfu Li, Wei-Dong Chen, Ruifang Hou, Dongbin Yang, Yan-Dong Wang
, RSC Adv.
, 2022
, 12
, 3618