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- Novel solid forms of insomnia drug suvorexant with improved solubility and dissolution: accessing salts from a salt solvate route. Suman Gundlapalli, Ramesh Devarapalli, Ramesh Reddy Mudda, Ramanaiah Chennuru, Ravichandrababu Rupakula
, CrystEngComm
, 2021
, 23
, 7739
- Synthesis and biological activity evaluation of azacycloheptane sulfonamide derivatives as potential orexin receptor antagonists. Bin Guo, Jingya Xiu, Yi Shen, Qingeng Li
, RSC Adv.
, 2020
, 10
, 30683
- Discovery and optimisation of 1-acyl-2-benzylpyrrolidines as potent dual orexin receptor antagonists. Jodi T. Williams, John Gatfield, Catherine Roch, Alexander Treiber, Francois Jenck, Martin H. Bolli, Christine Brotschi, Thierry Sifferlen, Bibia Heidmann, Christoph Boss
, Med. Chem. Commun.
, 2015
, 6
, 1054
- Discovery of HTL6641, a dual orexin receptor antagonist with differentiated pharmacodynamic properties. John A. Christopher, Sarah J. Aves, Jason Brown, James C. Errey, Suki S. Klair, Christopher J. Langmead, Oliver J. Mace, Richard Mould, Jayesh C. Patel, Benjamin G. Tehan, Andrei Zhukov, Fiona H. Marshall, Miles Congreve
, Med. Chem. Commun.
, 2015
, 6
, 947
- Palladium-catalyzed direct C–H ethoxycarbonylation of 2-aryl-1,2,3-triazoles and efficient synthesis of suvorexant. Rui Sang, Yang Zheng, Hailong Zhang, Xiaohua Wu, Qiantao Wang, Li Hai, Yong Wu
, Org. Chem. Front.
, 2018
, 5
, 648
- Regioselective halogenation of 2-substituted-1,2,3-triazoles via sp2 C–H activation. Qingshan Tian, Xianmin Chen, Wei Liu, Zechao Wang, Suping Shi, Chunxiang Kuang
, Org. Biomol. Chem.
, 2013
, 11
, 7830
- Continuous flow-mode synthesis of (chiral) amines with transaminase: a strategic biocatalytic approach to essential building blocks. Hippolyte Meersseman Arango, Ludivine van den Biggelaar, Patrice Soumillion, Patricia Luis, Tom Leyssens, Francesca Paradisi, Damien P. Debecker
, React. Chem. Eng.
, 2023
, 8
, 1505
- Biocatalytic reductive aminations with NAD(P)H-dependent enzymes: enzyme discovery, engineering and synthetic applications. Bo Yuan, Dameng Yang, Ge Qu, Nicholas J. Turner, Zhoutong Sun
, Chem. Soc. Rev.
, 2024
, 53
, 227
- Hot off the Press. Robert A. Hill, Andrew Sutherland
, Nat. Prod. Rep.
, 2020
, 37
, 1294
- Iridium-catalyzed direct asymmetric reductive amination of aromatic ketones. Haizhou Huang, Zitong Wu, Guorui Gao, Le Zhou, Mingxin Chang
, Org. Chem. Front.
, 2017
, 4
, 1976