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- Continuous flow-mode synthesis of (chiral) amines with transaminase: a strategic biocatalytic approach to essential building blocks. Hippolyte Meersseman Arango, Ludivine van den Biggelaar, Patrice Soumillion, Patricia Luis, Tom Leyssens, Francesca Paradisi, Damien P. Debecker
, React. Chem. Eng.
, 2023
, 8
, 1505
- Improving the IR spectra alignment algorithm with spectra deconvolution and combination with Raman or VCD spectroscopy. Lennard Böselt, Roy Aerts, Wouter Herrebout, Sereina Riniker
, Phys. Chem. Chem. Phys.
, 2023
, 25
, 2063
- Discovery of HTL6641, a dual orexin receptor antagonist with differentiated pharmacodynamic properties. John A. Christopher, Sarah J. Aves, Jason Brown, James C. Errey, Suki S. Klair, Christopher J. Langmead, Oliver J. Mace, Richard Mould, Jayesh C. Patel, Benjamin G. Tehan, Andrei Zhukov, Fiona H. Marshall, Miles Congreve
, Med. Chem. Commun.
, 2015
, 6
, 947
- Radical hydroxymethylation of alkyl iodides using formaldehyde as a C1 synthon. Lewis Caiger, Conar Sinton, Timothée Constantin, James J. Douglas, Nadeem S. Sheikh, Fabio Juliá, Daniele Leonori
, Chem. Sci.
, 2021
, 12
, 10448
- Mechanistic studies and radiofluorination of structurally diverse pharmaceuticals with spirocyclic iodonium(iii) ylides. Benjamin H. Rotstein, Lu Wang, Richard Y. Liu, Jon Patteson, Eugene E. Kwan, Neil Vasdev, Steven H. Liang
, Chem. Sci.
, 2016
, 7
, 4407
- Recent advances in the asymmetric synthesis of pharmacology-relevant nitrogen heterocycles via stereoselective aza-Michael reactions. Maxim G. Vinogradov, Olga V. Turova, Sergei G. Zlotin
, Org. Biomol. Chem.
, 2019
, 17
, 3670
- Transaminase biocatalysis: optimization and application. Fei Guo, Per Berglund
, Green Chem.
, 2017
, 19
, 333
- Synthesis of substituted piperidines by enantioselective desymmetrizing intramolecular aza-Michael reactions. Marta Guerola, Marcos Escolano, Gloria Alzuet-Piña, Enrique Gómez-Bengoa, Carmen Ramírez de Arellano, María Sánchez-Roselló, Carlos del Pozo
, Org. Biomol. Chem.
, 2018
, 16
, 4650