Results
1 -
10 of
10
(Click
here to explore results)
- Synthesis of N-substituted ε-hexonolactams as pharmacological chaperones for the treatment of N370S mutant Gaucher disease. Guan-Nan Wang, Gabriele Twigg, Terry D. Butters, Siwei Zhang, Liangren Zhang, Li-He Zhang, Xin-Shan Ye
, Org. Biomol. Chem.
, 2012
, 10
, 2923
- Concise asymmetric synthesis of new enantiomeric C-alkyl pyrrolidines acting as pharmacological chaperones against Gaucher disease. Tessa Castellan, Virginie Garcia, Frédéric Rodriguez, Isabelle Fabing, Yevhenii Shchukin, My Lan Tran, Stéphanie Ballereau, Thierry Levade, Yves Génisson, Cécile Dehoux
, Org. Biomol. Chem.
, 2020
, 18
, 7852
- Bicyclic isoureas derived from 1-deoxynojirimycin are potent inhibitors of β-glucocerebrosidase. Alen Sevšek, Maša Čelan, Bibi Erjavec, Linda Quarles van Ufford, Javier Sastre Toraño, Ed E. Moret, Roland J. Pieters, Nathaniel I. Martin
, Org. Biomol. Chem.
, 2016
, 14
, 8670
- Orthoester functionalized N-guanidino derivatives of 1,5-dideoxy-1,5-imino-d-xylitol as pH-responsive inhibitors of β-glucocerebrosidase. Alen Sevšek, Javier Sastre Toraño, Linda Quarles van Ufford, Ed E. Moret, Roland J. Pieters, Nathaniel I. Martin
, Med. Chem. Commun.
, 2017
, 8
, 2050
- Bicyclic (galacto)nojirimycin analogues as glycosidase inhibitors: Effect of structural modifications in their pharmacological chaperone potential towards β-glucocerebrosidase. Matilde Aguilar-Moncayo, M. Isabel García-Moreno, Ana Trapero, Meritxell Egido-Gabás, Amadeu Llebaria, José M. García Fernández, Carmen Ortiz Mellet
, Org. Biomol. Chem.
, 2011
, 9
, 3698
- Synthesis and biological evaluation of d-gluconhydroximo-1,5-lactam and its oxime-substituted derivatives as pharmacological chaperones for the treatment of Gaucher disease. Jiajia Wang, Xiaomin Wang, Yunyan Zhao, Xiaoyao Ma, Yue Wan, Zhongwei Chen, Hao Chen, Hao Gan, Jing Li, Lei Li, Peng George Wang, Wei Zhao
, Med. Chem. Commun.
, 2016
, 7
, 365
- Cyclodextrin-mediated crystallization of acid β-glucosidase in complex with amphiphilic bicyclic nojirimycin analogues. Boris Brumshtein, Matilde Aguilar-Moncayo, Juan M. Benito, José M. García Fernandez, Israel Silman, Yoseph Shaaltiel, David Aviezer, Joel L. Sussman, Anthony H. Futerman, Carmen Ortiz Mellet
, Org. Biomol. Chem.
, 2011
, 9
, 4160
- Glycomimetic-based pharmacological chaperones for lysosomal storage disorders: lessons from Gaucher, GM1-gangliosidosis and Fabry diseases. Elena M. Sánchez-Fernández, José M. García Fernández, Carmen Ortiz Mellet
, Chem. Commun.
, 2016
, 52
, 5497
- Adamantane substituted aminocyclitols as pharmacological chaperones for Gaucher disease. Ana Trapero, Meritxell Egido-Gabás, Amadeu Llebaria
, Med. Chem. Commun.
, 2013
, 4
, 1584
- Beyond substrate analogues: new inhibitor chemotypes for glycosyltransferases. Lauren Tedaldi, Gerd K. Wagner
, Med. Chem. Commun.
, 2014
, 5
, 1106