Date Severity Status Feedback
Jul 16 2015 5:37AM Normal Acknowledged You wrote down in the name section that Ranitidine is the Z isomer. However, other websites have been listing the formula as the E isomer. I wasn't able to decipher if E/Z isomerism is important and if so in which isomer it resides.
I'm not sure how you got to this record but a search on the name ranitidine would have returned this record and the record for the structure with undefined stereochemistry - it now returns the E-, Z- and EZ- records. Cases like this are often difficult as if E/Z stereochemistry is unspecified it is common that due to the way the structure is depicted double bond geometry is unintentionallty added. Looking at the INN documents and other sources it appears that the name Ranitidine probably refers to the compound with unspecified geometry: http://www.chemspider.com/Chemical-Structure.4863.html I have curated all three isomers to try to clarify the relationships.
Jul 15 2013 9:25AM Normal Acknowledged This appears to be a duplicate entry with http://www.chemspider.com/Chemical-Structure.4863.html This record appears to have more information and references than 4863.
Thank you for your feedback. The two structures in these records are slightly different - This record has defined double bond geometry, and record 4863 has unspecified double bond geometry.
Aug 23 2012 10:00AM Normal Acknowledged Why are there two entries - ChemSpider ID 4863 and 571453?
The two entries correspond to 2 slightly different structures, this record has a defined double bond geometry, while 4863 corresponds to a structure with an undefined geometry, such cases are difficult to deal with as they often describe the same molecule viewed from a different perspective. It is likely the barrier to interconversion is low but it might be that one geometry is preferred.