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Developing an adult stem cell derived microphysiological intestinal system for predicting oral prodrug bioconversion and permeability in humans . Abhinav Sharma, Liang Jin, Xue Wang, Yue-Ting Wang, David M. Stresser
, Lab Chip
, 2024
, 24
, 339
Common precursor strategy for the synthesis of bestatin, amprenavir intermediate and syn -4-hydroxy-5-phenyl-γ-lactam . Brijesh Kumar, Mushtaq A. Aga, Abdul Rouf, Bhahwal A. Shah, Subhash C. Taneja
, RSC Adv.
, 2014
, 4
, 17206
New approaches to the industrial synthesis of HIV protease inhibitors . Yutaka Honda, Satoshi Katayama, Mitsuhiko Kojima, Takayuki Suzuki, Naomi Kishibata, Kunisuke Izawa
, Org. Biomol. Chem.
, 2004
, 2
, 2061
Microtiter plate based chemistry and in situ screening: a useful approach for rapid inhibitor discovery . Ashraf Brik, Chung-Yi Wu, Chi-Huey Wong
, Org. Biomol. Chem.
, 2006
, 4
, 1446
Revealing the binding and drug resistance mechanism of amprenavir, indinavir, ritonavir, and nelfinavir complexed with HIV-1 protease due to double mutations G48T/L89M by molecular dynamics simulations and free energy analyses . Rui-Ge Wang, Hong-Xing Zhang, Qing-Chuan Zheng
, Phys. Chem. Chem. Phys.
, 2020
, 22
, 4464
Biocatalytic routes to anti-viral agents and their synthetic intermediates . Sjoerd Slagman, Wolf-Dieter Fessner
, Chem. Soc. Rev.
, 2021
, 50
, 1968
Discovery of GS-8374, a potent human immunodeficiency virus type 1 protease inhibitor with a superior resistance profile . Gong-Xing He, Zheng-Yu Yang, Matthew Williams, Christian Callebaut, Tomas Cihlar, Bernard P. Murray, Chris Yang, Michael L. Mitchell, Hongtao Liu, Jianying Wang, Murty Arimilli, Eugene Eisenberg, Kirsten M. Stray, Luong K. Tsai, Marcos Hatada, Xiaowu Chen, James M. Chen, Yujin Wang, Melody S. Lee, Robert G. Strickley, Quynh Iwata, Xubin Zheng, Choung U. Kim, Swami Swaminathan, Manoj C. Desai, William A. Lee, Lianhong Xu
, Med. Chem. Commun.
, 2011
, 2
, 1093
Drug resistance mechanisms of three mutations V32I, I47V and V82I in HIV-1 protease toward inhibitors probed by molecular dynamics simulations and binding free energy predictions . Jianzhong Chen
, RSC Adv.
, 2016
, 6
, 58573
Potent HIV-1
protease inhibitors incorporating meso -bicyclic urethanes as P2-ligands: structure-based design, synthesis, biological evaluation and protein –ligand X-ray studies . Arun K. Ghosh, Sandra Gemma, Jun Takayama, Abigail Baldridge, Sofiya Leshchenko-Yashchuk, Heather B. Miller, Yuan-Fang Wang, Andrey Y. Kovalevsky, Yashiro Koh, Irene T. Weber, Hiroaki Mitsuya
, Org. Biomol. Chem.
, 2008
, 6
, 3703
Computational analysis of macrolides as SARS-CoV-2 main protease inhibitors: a pattern recognition study based on molecular topology and validated by molecular docking . Riccardo Zanni, Maria Galvez-Llompart, Jorge Galvez
, New J. Chem.
, 2021
, 45
, 8654