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- Discovery and optimisation of 1-acyl-2-benzylpyrrolidines as potent dual orexin receptor antagonists. Jodi T. Williams, John Gatfield, Catherine Roch, Alexander Treiber, Francois Jenck, Martin H. Bolli, Christine Brotschi, Thierry Sifferlen, Bibia Heidmann, Christoph Boss
, Med. Chem. Commun.
, 2015
, 6
, 1054
- Enantioselective synthesis of almorexant via iridium-catalysed intramolecular allylic amidation. Martín Fañanás-Mastral, Johannes F. Teichert, José Antonio Fernández-Salas, Dorus Heijnen, Ben L. Feringa
, Org. Biomol. Chem.
, 2013
, 11
, 4521
- Chemistry and biology of orexin signaling. Thomas Kodadek, Di Cai
, Mol. BioSyst.
, 2010
, 6
, 1366
- Discovery of HTL6641, a dual orexin receptor antagonist with differentiated pharmacodynamic properties. John A. Christopher, Sarah J. Aves, Jason Brown, James C. Errey, Suki S. Klair, Christopher J. Langmead, Oliver J. Mace, Richard Mould, Jayesh C. Patel, Benjamin G. Tehan, Andrei Zhukov, Fiona H. Marshall, Miles Congreve
, Med. Chem. Commun.
, 2015
, 6
, 947
- Synthesis and characterization of a novel 18F-labeled 2,5-diarylnicotinamide derivative targeting orexin 2 receptor. Hiroyuki Watanabe, Naoki Matsushita, Yoichi Shimizu, Shimpei Iikuni, Yuji Nakamoto, Kaori Togashi, Masahiro Ono
, Med. Chem. Commun.
, 2019
, 10
, 2126
- Computational design of syntheses leading to compound libraries or isotopically labelled targets. Karol Molga, Piotr Dittwald, Bartosz A. Grzybowski
, Chem. Sci.
, 2019
, 10
, 9219
- Introduction of chirality at C1 position of 1-substituted-3,4-dihydroisoquinoline by its enantioselective reduction: synthesis of chiral 1-substituted-1,2,3,4-tetrahydroisoquinoline – a review. Md. Moaz Ahmed Asif, Susmita Roy Lisa, Nazmul Qais
, RSC Adv.
, 2023
, 13
, 11010
- Chemistry of detrifluoroacetylatively in situ generated fluoro-enolates. Haibo Mei, Jiang Liu, Santos Fustero, Raquel Román, Renzo Ruzziconi, Vadim A. Soloshonok, Jianlin Han
, Org. Biomol. Chem.
, 2019
, 17
, 762
- Polycyclic indole alkaloid-type compounds by MCR. Wei Wang, Eberhardt Herdtweck, Alexander Dömling
, Chem. Commun.
, 2010
, 46
, 770
- Synthesis and biological activity evaluation of azacycloheptane sulfonamide derivatives as potential orexin receptor antagonists. Bin Guo, Jingya Xiu, Yi Shen, Qingeng Li
, RSC Adv.
, 2020
, 10
, 30683