Novel coordination polymers, their pharmaceutical formulations, useful for treating atheroma, tumors and other neoplastic tissue, as well as other conditions that are responsive to the induction of targeted oxidative stress, are disclosed.
Darren Magda, Nikolay Gerasimchuk, Philip Lecane, Richard A. Miller, John E. Biaglow and Jonathan L. Sessler.
Motexafin gadolinium reacts with ascorbate to produce reactive oxygen species, Chem. Commun., 2002, 0, 2730.
Wen-Hao Wei, Mark Fountain, Darren Magda, Zhong Wang, Phil Lecane, Mimi Mesfin, Dale Miles and Jonathan L. Sessler.
Gadolinium texaphyrin–methotrexate conjugates. Towards improved cancer chemotherapeutic agents, Org. Biomol. Chem., 2005, 3, 3290.
Jonathan F. Arambula, Jonathan L. Sessler and Zahid H. Siddik.
A texaphyrin–oxaliplatin conjugate that overcomes both pharmacologic and molecular mechanisms of cisplatin resistance in cancer cells, Med. Chem. Commun., 2012, 3, 1275.