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10Topoisomerase I Inhibitors: Chemical Biology, DNA Topoisomerases and Cancer Topoisomerase I Inhibitors u2013 The Camptothecins, Cancer Management in Man: Chemotherapy, Biological Therapy, Hyperthermia and Supporting Measures A multi-centre dose-escalation and pharmacokinetic study of diflomotecan in patients with advanced malignancy, Cancer Chemotherapy and Pharmacology Population pharmacokinetic/pharmacodynamic modeling of drug-induced adverse effects of a novel homocamptothecin analog, elomotecan (BN80927), in a Phase I dose finding study in patients with advanced solid tumors, Cancer Chemotherapy and Pharmacology Phase I dose-finding study and a pharmacokinetic/pharmacodynamic analysis of the neutropenic response of intravenous diflomotecan in patients with advanced malignant tumours, Cancer Chemotherapy and Pharmacology Single nucleotide polymorphisms modify the transporter activity of ABCG2, Cancer Chemotherapy and Pharmacology Predictive ability of a semi-mechanistic model for neutropenia in the development of novel anti-cancer agents: two case studies, Investigational New Drugs