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4Pharmacology, Clinical Efficacy, and Tolerability of Phosphodiesterase-4 Inhibitors: Impact of Human Pharmacokinetics, Phosphodiesterases as Drug Targets Medical therapy for ulcerative colitis: The state of the art and beyond, Current Gastroenterology Reports Phosphodiesterase Inhibitors for Chronic Obstructive Pulmonary Disease: What Does the Future Hold?, Drugs Phosphodiesterase 4-targeted treatments for autoimmune diseases, BMC Medicine