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5Plasma Nucleoside and Base Levels Following Treatment with the New Thymidylate Synthetase Inhibitor CB 3717, Purine Metabolism in Man-IV Inhibition of Thymidylate Synthetase by the New Quinazoline Antifolate, CB 3717; Enzyme Purification and Kinetics, Purine Metabolism in Man-IV Early Clinical Studies with CB 3717 (N-(4-(N-((2-Amino-4-Hydroxy-6-Quinazolinyl)Methyl)Prop-2-Ynylamino)Benzoyl)-L-Glutamic Acid) at the Royal Marsden Hospital, Cancer Chemotherapy and Selective Drug Development