Kelley, J. L., Musso D.L., Boswell G.E..
(2S,3S,5R)-2-(3,5-difluorophenyl)-3,5-dimethyl-2-morpholinol: a novel antidepressant agent and selective inhibitor of norepinephrine uptake, J. Med. Chem.The phenylmorpholinol, its asymmetric synthesis and biological data are presented. The compound was also known as BW1555U and GW320659A. It is a potent inhibitor of norepinephrine and, to a lesser extent, dopamine uptake with no effect on 5-HT uptake. Good oral bioavailability and apparent efficacy in a tetrabenazine model of depression in mice.