Robert H. Feling, Greg O. Buchanan, Tracy J. Mincer, Christopher A. Kauffman, Paul R. Jensen, and WilliamF enical.
Salinosporamide A: A Highly Cytotoxic Proteasome Inhibitor from a Novel Microbial Source, a Marine Bacterium of the New Genus Salinospora, Angew. Chem. Int. Ed. 2003, 42(3), 355-357Comprehensive analysis of 2D NMR data, including the results of COSY, HMQC, and HMBC experiments, enabled the complete planar structure of salinosporamide A to be
assigned, as in 1, to a 2-aza-oxabicyclo[3.2.0]heptane-3,7-dione skeleton substituted with cyclohexenylcarbinol and chloroethyl side chains.