ChemSpider 2D Image | elacridar | C34H33N3O5

elacridar

  • Molecular FormulaC34H33N3O5
  • Average mass563.643 Da
  • Monoisotopic mass563.242004 Da
  • ChemSpider ID106620

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

143664-11-3 [RN]
4-Acridinecarboxamide, N-[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-9,10-dihydro-5-methoxy-9-oxo- [ACD/Index Name]
AR7621300
elacridar [INN]
elacridar [Spanish] [INN]
élacridar [French] [INN]
elacridarum [Latin] [INN]
GF120918
GG918
GW0918
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

7582 [DBID]
GF 120918 [DBID]
GF-120918 [DBID]
GG 918 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      BCRP inhibitor TargetMol T2657

    • Bio Activity:

      BCRP/P-gp TargetMol T2657
      Elacridar (GF120918; GW0918) is a P-glycoprotein inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disp osition of various test molecules. MedChem Express
      Elacridar (GF120918; GW0918) is a P-glycoprotein inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules.; IC50 value:; Target: P-glycoprotein ; In vitro, GF120918A demonstrated high plasma protein binding across species, although a definitive protein binding evaluation was precluded by poor recovery, particularly in buffer and in mouse, rat, and dog plasma. MedChem Express HY-50879
      Elacridar (GF120918; GW0918) is a P-glycoprotein inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules.;IC50 value:;Target: P-glycoprotein ;In vitro, GF120918A demonstrated high plasma protein binding across species, although a definitive protein binding evaluation was precluded by poor recovery, particularly in buffer and in mouse, rat, and dog plasma. GF120918A did not demonstrate potent inhibition of several human cytochrome P450 enzymes evaluated in vitro, with IC(50) values well above concentrations anticipated to be achieved in vivo. Together, these data confirm the utility of GF120918A as a tool P-glycoprotein inhibitor in preclinical species and offer additional guidance on preclinical dose regimens likely to produce P-glycoprotein-mediated effects. MedChem Express HY-50879
      Membrane Tranporter/Ion Channel MedChem Express HY-50879
      Membrane Tranporter/Ion Channel; MedChem Express HY-50879
      Membrane Transporter/Ion Channel TargetMol T2657
      P-glycoprotein MedChem Express HY-50879

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.3±0.1 g/cm3
Boiling Point: 701.6±60.0 °C at 760 mmHg
Vapour Pressure: 0.0±2.2 mmHg at 25°C
Enthalpy of Vaporization: 102.7±3.0 kJ/mol
Flash Point: 378.1±32.9 °C
Index of Refraction: 1.644
Molar Refractivity: 161.4±0.3 cm3
#H bond acceptors: 8
#H bond donors: 2
#Freely Rotating Bonds: 8
#Rule of 5 Violations: 2
ACD/LogP: 5.55
ACD/LogD (pH 5.5): 3.70
ACD/BCF (pH 5.5): 112.90
ACD/KOC (pH 5.5): 239.80
ACD/LogD (pH 7.4): 5.39
ACD/BCF (pH 7.4): 5535.33
ACD/KOC (pH 7.4): 11757.12
Polar Surface Area: 89 Å2
Polarizability: 64.0±0.5 10-24cm3
Surface Tension: 53.8±3.0 dyne/cm
Molar Volume: 445.6±3.0 cm3

Click to predict properties on the Chemicalize site


Advertisement