ChemSpider 2D Image | Fosamprenavir calcium | C25H34CaN3O9PS

Fosamprenavir calcium

  • Molecular FormulaC25H34CaN3O9PS
  • Average mass623.669 Da
  • Monoisotopic mass623.137939 Da
  • ChemSpider ID116244

  • Charge - Charge

    defined stereocentres - 3 of 3 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

226700-81-8 [RN]
calcium (1R,2S)-1-({[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}methyl)-3-phenyl-2-({[(3S)-tetrahydrofuran-3-yloxy]carbonyl}amino)propyl phosphate
Calcium (2R,3S)-1-{[(4-aminophenyl)sulfonyl](isobutyl)amino}-4-phenyl-3-({[(3S)-tetrahydro-3-furanyloxy]carbonyl}amino)-2-butanyl phosphate [ACD/IUPAC Name]
Calcium (3S) tetrahydro-3-furanyl(1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)amino]-1 -benzyl-2-(phosphonooxy)propylcarbamate
Calcium-(1R,2S)-1-({[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}methyl)-3-phenyl-2-({[(3S)-tetrahydrofuran-3-yloxy]carbonyl}amino)propylphosphat
Calcium-(2R,3S)-1-{[(4-aminophenyl)sulfonyl](isobutyl)amino}-4-phenyl-3-({[(3S)-tetrahydro-3-furanyloxy]carbonyl}amino)-2-butanylphosphat [German] [ACD/IUPAC Name]
carbamic acid, [(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-1-(phenylmethyl)-2-(phosphonooxy)propyl]-, (3S)-tetrahydro-3-furanyl ester, calcium salt (1:1)
Carbamic acid, N-[(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-1-(phenylmethyl)-2-(phosphonooxy)propyl]-, (3S)-tetrahydro-3-furanyl ester, calcium salt (1:1) [ACD/Index Name]
Fosamprenavir (Calcium Salt)
Fosamprenavir calcium [USAN]
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

D03835 [DBID]
GW-433908 [DBID]
VX-175 [DBID]
  • Miscellaneous

    • Bio Activity:

      Anti-infection MedChem Express HY-17431
      Anti-infection; Metabolism/Protease; MedChem Express HY-17431
      GW433908 is a phosphate ester prodrug of the antiretroviral protease inhibitor amprenavir, with improved solubility over the parent molecule and a potential for reduced pill burden on current dosing r egimens; GW433908G is the calcium salt of the prodrug. MedChem Express
      GW433908 is a phosphate ester prodrug of the antiretroviral protease inhibitor amprenavir, with improved solubility over the parent molecule and a potential for reduced pill burden on current dosing regimens; GW433908G is the calcium salt of the prodrug.; IC50 Value:; Target: HIV Protease; in vitro: There were no significant changes in buprenorphine or PI plasma levels and no significant changes in medication adverse effects or opioid withdrawal. MedChem Express HY-17431
      GW433908 is a phosphate ester prodrug of the antiretroviral protease inhibitor amprenavir, with improved solubility over the parent molecule and a potential for reduced pill burden on current dosing regimens; GW433908G is the calcium salt of the prodrug.;IC50 Value:;Target: HIV Protease;In vitro: There were no significant changes in buprenorphine or PI plasma levels and no significant changes in medication adverse effects or opioid withdrawal. Increased concentrations of the inactive metabolite buprenorphine-3-glucuronide suggested that darunavir-ritonavir and fosamprenavir-ritonavir induced glucuronidation of buprenorphine[1].;In vivo: Fosamprenavir-ritonavir administered with methadone did not alter plasma amprenavir pharmacokinetics compared with historical control data; nor did it alter the unbound R-methadone at 2 and 6 hours after methadone dosing. Pharmacodynamic indexes remained essentially unchanged after adding fosamprenavir-ritonavir to methadone [2]. After a high-fat MedChem Express HY-17431
      HIV MedChem Express HY-17431
      HIV HIV Protease MedChem Express HY-17431

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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