ChemSpider 2D Image | SKF-38393 Hydrochloride | C16H18ClNO2

SKF-38393 Hydrochloride

  • Molecular FormulaC16H18ClNO2
  • Average mass291.773 Da
  • Monoisotopic mass291.102600 Da
  • ChemSpider ID130083

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(±)-1-Phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diol hydrochloride
(±)-SKF-38393 hydrochloride
1H-3-Benzazepine-7,8-diol, 2,3,4,5-tetrahydro-1-phenyl-, hydrochloride
1H-3-Benzazepine-7,8-diol, 2,3,4,5-tetrahydro-1-phenyl-, hydrochloride (1:1) [ACD/Index Name]
1-Phenyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7,8-diolhydrochlorid (1:1) [German] [ACD/IUPAC Name]
1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol hydrochloride
1-Phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol hydrochloride (1:1) [ACD/IUPAC Name]
1-Phényl-2,3,4,5-tétrahydro-1H-3-benzazépine-7,8-diol, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
1-Phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol hydrochloride
2,3,4,5-Tetrahydro-1-phenyl-1H-3-benzazepine-7,8-diol hydrochloride
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

D047_SIGMA [DBID]
EU-0100436 [DBID]
SKF 38393A [DBID]
SKF38393 [DBID]
  • References
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Chemical Class:

      Dopamine EU-OpenScreen [D-047]

    • Bio Activity:

      <p>Prototypic, selective D<sub>1</sub>-like dopamine receptor partial agonist (K<sub>i</sub> values are 1 and ~ 0.5 nM at D<sub>1</sub>-like receptors (D<sub>1</sub> and D<sub>5</sub>) and ~ 150, ~ 5000 and ~ 1000 nM at D<sub>2</sub>-like receptors (D<sub>2</sub>, D<sub>3</sub> and D<sub>4</sub>) respectively). Hydrochloride salt.</p> <p><br />SKF 38393 facilitates long term potentiation (LTP) via D<sub>1</sub> and D<sub>5</sub> activation and has also been shown to presynaptically stimulate glutamate release in the hippocampus.</p> <p>Additionally activates the HPA axis to increase ACTH and corticosterone levels.</p> <p>Shows proconvulsant and anorexic effects.</p> <p>Blood brain barrier permeable.</p> <p>Active in vivo.</p> <p><br /><a href="/skf-38393-hydrobromide.html" title="SKF 3893 hydrobromide also available | Hello Bio" target="_self">SKF 38393 hydrobromide</a> also available.</p> Hello Bio HB6111
      <p>Prototypic, selective D<sub>1</sub>-like dopamine receptor partial agonist (K<sub>i</sub> values are 1 and ~ 0.5 nM at D<sub>1</sub>-like receptors (D<sub>1</sub> and D<sub>5</sub>) and ~ 150, ~ 5000 and ~ 1000 nM at D<sub>2</sub>-like receptors (D<sub>2</sub>, D<sub>3</sub> and D<sub>4</sub>) respectively). Hydrochloride salt.</p> <p><br />SKF 38393 facilitates long term potentiation (LTP) via D<sub>1</sub> and D<sub>5</sub> activation and has also been shown to presynaptically stimulate glutamate release in the hippocampus.</p> <p>Additionally activates the HPA axis to increase ACTH and corticosterone levels.</p> <p>Shows proconvulsant and anorexic effects.</p> <p>Blood brain barrier permeable.</p> <p>Active in vivo.</p> <p><br /><a href=/skf-38393-hydrobromide.html title=SKF 3893 hydrobromide also available | Hello Bio target=_self>SKF 38393 hydrobromide</a> also available.</p> Hello Bio HB6111
      Biochemicals & small molecules/Agonists & activators Hello Bio HB6111
      Dopamine Receptor MedChem Express HY-12520A
      GPCR/G protein MedChem Express HY-12520A
      GPCR/G protein; Neuronal Signaling; MedChem Express HY-12520A
      Prototypic, selective D<sub>1</sub>-like receptor partial agonist Hello Bio HB6111
      Receptors & Transporters/G protein coupled receptors/Dopamine/D1-like/D<sub>1</sub> Hello Bio HB6111
      SKF 38393 hydrochloride is a D1 agonist with IC50 of 110 nM.; IC50 value: 110 nM [1]; Target: D1 agonist; in vitroL SKF 38393 hydrochloride is a benzazepine selective agonist of the D1DR (dopamine D1 receptor). MedChem Express HY-12520A
      SKF 38393 hydrochloride is a D1 agonist with IC50 of 110 nM.;IC50 value: 110 nM [1];Target: D1 agonist;In vitroL SKF 38393 hydrochloride is a benzazepine selective agonist of the D1DR (dopamine D1 receptor). Agonism of the D1DR by SKF 38393 is correlated to induced desynchronization of electroencephalographic activity in rats. SKF 38393 is also reported to demonstrate agonism of the serotonin SR-2C (5-HT1C receptor). SKF 38393 HCl is an activator of D5DR. SKF 38393 is a synthetic compound of the benzazepine chemical class which acts as a selective D1/D5 receptor partial agonist. It has stimulant and anorectic effects. SKF-38393 enhances the frequency of mEPSCs in a concentration-dependent manner. SKF-38393 enhances the frequency of mEPSCs in a concentration-dependent manner. [2] MedChem Express HY-12520A

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

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