ChemSpider 2D Image | Atipamezole hydrochloride | C14H17ClN2

Atipamezole hydrochloride

  • Molecular FormulaC14H17ClN2
  • Average mass248.751 Da
  • Monoisotopic mass248.108032 Da
  • ChemSpider ID13077441

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

104075-48-1 [RN]
1H-Imidazole, 5-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-, hydrochloride (1:1) [ACD/Index Name]
4-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole hydrochloride
4-(2-Ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole hydrochloride (1:1) [ACD/IUPAC Name]
4-(2-Éthyl-2,3-dihydro-1H-indén-2-yl)-1H-imidazole, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
4-(2-Ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazolhydrochlorid (1:1) [German] [ACD/IUPAC Name]
5-(2-Ethyl-2,3-dihydro-1H-indene-2-yl)-1H-imidazole hydrochloride
Atipamezole (hydrochloride)
Atipamezole hydrochloride
'104075-48-1 [EINECS]
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

2W4279571X [DBID]
CCRIS 4693 [DBID]
UNII:2W4279571X [DBID]
UNII-2W4279571X [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      7-TM Receptors Tocris Bioscience 2937
      Adrenergic Alpha-2 Receptors Tocris Bioscience 2937
      Adrenergic Receptor MedChem Express HY-12380
      Adrenergic Receptors Tocris Bioscience 2937
      Atipamezole Hcl(MPV1248 Hcl) is an alpha-adrenoceptor antagonist with high affinity and selectivity for the alpha 2-receptor. MedChem Express
      Atipamezole Hcl(MPV1248 Hcl) is an alpha-adrenoceptor antagonist with high affinity and selectivity for the alpha 2-receptor.; IC50 value:; Target: alpha2-adrenoceptor antagonist; in vitro: The alpha2-adrenoceptor antagonist atipamezole was a potent inhibitor of aldosterone release (range 10-1000 nM) [1]. MedChem Express HY-12380
      Atipamezole Hcl(MPV1248 Hcl) is an alpha-adrenoceptor antagonist with high affinity and selectivity for the alpha 2-receptor.;IC50 value:;Target: alpha2-adrenoceptor antagonist;In vitro: The alpha2-adrenoceptor antagonist atipamezole was a potent inhibitor of aldosterone release (range 10-1000 nM) [1]. In receptor binding studies [( 3H]-clonidine and [3H]-prazosin displacement) an alpha 2/alpha 1 selectivity ratio of 8526 was obtained for atipamezole, while idazoxan and yohimbine showed ratios of 27 and 40, respectively. Atipamezole had also about a 100 times higher affinity on alpha 2-adrenoceptors than the reference compounds [3].;In vivo: In vivo studies of [3H]atipamezole demonstrated good penetration into the brain (0.3-1.8% injected dose/g at 5 min, depending upon brain region). In addition, [3H]atipamezole displayed rapid in vivo clearance of nonspecific binding such that at 1 h following an i.v. injection of the drug (100 microCi/animal, rat tail vein administration) the MedChem Express HY-12380
      GPCR/G protein MedChem Express HY-12380
      GPCR/G protein; MedChem Express HY-12380
      Selective ?2 antagonist Tocris Bioscience 2937
      Selective ?2-adrenergic receptor antagonist (Ki values are 1.1, 1.0, 0.89, 1300 and 6500 nM for ?2A, ?2B, ?2C, ?1A and ?1B receptors respectively). Brain penetrant. Tocris Bioscience 2937
      Selective alpha2 antagonist Tocris Bioscience 2937
      Selective alpha2-adrenergic receptor antagonist (Ki values are 1.1, 1.0, 0.89, 1300 and 6500 nM for alpha2A, alpha2B, alpha2C, alpha1A and alpha1B receptors respectively). Brain penetrant. Tocris Bioscience 2937

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


Advertisement