ChemSpider 2D Image | cyproheptadine | C21H22ClN

cyproheptadine

  • Molecular FormulaC21H22ClN
  • Average mass323.859 Da
  • Monoisotopic mass323.144073 Da
  • ChemSpider ID13173

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1-Methyl-4-(5-dibenzo[a,e]cycloheptatrienylidene)piperidine hydrochloride
1-Methyl-4-(5H-dibenzo[a,e]cycloheptatrienylidene)piperidine Hydrochloride
213-535-1 [EINECS]
4-(5H-Dibenzo[a,d][7]annulen-5-yliden)-1-methylpiperidinhydrochlorid
4-(5H-Dibenzo[a,d][7]annulen-5-yliden)-1-methylpiperidinhydrochlorid (1:1) [German] [ACD/IUPAC Name]
4-(5H-dibenzo[a,d][7]annulén-5-ylidène)-1-méthylpipéridine chlorhydrate
4-(5H-dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine hydrochloride
4-(5H-Dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine hydrochloride (1:1) [ACD/IUPAC Name]
4-(5H-Dibenzo[a,d][7]annulén-5-ylidène)-1-méthylpipéridine, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine Hydrochloride
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

0S9323MCT0 [DBID]
VUFB 3511 [DBID]
3575322 [DBID]
AI3-26940 [DBID]
C6022_SIGMA [DBID]
EU-0100246 [DBID]
MLS000028462 [DBID]
NSC 169911 [DBID]
Prestwick_139 [DBID]
QA-9006 [DBID]
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  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Chemical Class:

      The hydrochloride salt of cyproheptadine. Note that the drug named cyproheptadine hydrochloride generally refers to cyproheptadine hydrochloride sesquihydrate. ChEBI CHEBI:59695, https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:59695

    • Therapeutical Effect:

      H1-antihistamine, antipruritic Rudolf Boehm Institute [01505973]

    • Compound Source:

      synthetic Rudolf Boehm Institute [01505973]

    • Bio Activity:

      5-HT Receptor MedChem Express HY-B0366A
      5-HT Receptors Tocris Bioscience 996
      5-HT2 antagonist Tocris Bioscience 0996, 996
      5-HT2 Receptors Tocris Bioscience 996
      7-TM Receptors Tocris Bioscience 996
      Biochemicals & small molecules/Antagonists & inhibitors Hello Bio [HB1657]
      Cyproheptadine is a histamine receptor antagonist for 5-HT2 receptor with IC50 of 0.6 nM. MedChem Express http://www.medchemexpress.com/Captopril.html, HY-B0366A
      Cyproheptadine is a histamine receptor antagonist for 5-HT2 receptor with IC50 of 0.6 nM. ;Target: 5-HT2 ReceptorCyproheptadine is a serotonin antagonist and a histamine H2 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc. Inhibitory effects of cyclobenzaprine, amitriptyline, and cyproheptadine on mono- and polysynaptic reflex potentials are due to the inhibition of descending serotonergic systems through 5-HT(2) receptors in the spinal cord [1, 2]. MedChem Express HY-B0366A
      GPCR/G protein MedChem Express HY-B0366A
      GPCR/G protein; Neuronal Signaling; MedChem Express HY-B0366A
      Non-selective 5HT<sub>2</sub> antagonist Hello Bio [HB1657]
      Non-selective 5HT<sub>2</sub> antagonist. Shows various biological effects. Active <em> in vivo</em>. Hello Bio [HB1657]
      Non-selective 5HT2 antagonist, migraine prophylactic. Tocris Bioscience 0996
      Non-selective 5HT2 antagonist, migraine prophylactic. Also SETD7/9 inhibitor (IC50 = 1?M). Decreases expression and increases degradation of estrogen receptor (ER) ? in breast tumor MCF7 cells. Inhibits growth of MCF7 xenografts in mice. Tocris Bioscience 996
      Non-selective 5HT2 antagonist, migraine prophylactic. Also SETD7/9 inhibitor (IC50 = 1muM). Decreases expression and increases degradation of estrogen receptor (ER) alpha in breast tumor MCF7 cells. Inhibits growth of MCF7 xenografts in mice. Tocris Bioscience 996
      Receptors & Transporters/G protein coupled receptors/5-HT/5-HT<sub>2</sub>/Non-selective Hello Bio [HB1657]

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

No predicted properties have been calculated for this compound.

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