ChemSpider 2D Image | manidipine dihydrochloride | C35H40Cl2N4O6

manidipine dihydrochloride

  • Molecular FormulaC35H40Cl2N4O6
  • Average mass683.621 Da
  • Monoisotopic mass682.232483 Da
  • ChemSpider ID132878

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

manidipine dihydrochloride
2-(4-Benzhydrylpiperazin-1-yl)ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate dihydrochloride
2,6-Diméthyl-4-(3-nitrophényl)-1,4-dihydro-3,5-pyridinedicarboxylate de 2-[4-(diphénylméthyl)-1-pipérazinyl]éthyle et de méthyle, dichlorhydrate [French] [ACD/IUPAC Name]
2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate dihydrochloride [ACD/IUPAC Name]
2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl-methyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridindicarboxylatdihydrochlorid [German] [ACD/IUPAC Name]
2-[4-(Diphenylmethyl)piperazin-1-yl]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate dihydrochloride
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester, hydrochloride (1:2) [ACD/Index Name]
89226-75-5 [RN]
Calslot [Trade name]
MANIDIPINE DIHYDROCHLORIDE, (R)-
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

0GIE8B995I [DBID]
CV 4093 [DBID]
CV-4093 [DBID]
D01553 [DBID]
E4997QG30G [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      Calcium Channel antagonist TargetMol T0193

    • Bio Activity:

      Calcium Channel MedChem Express HY-17403
      Calcium Channel TargetMol T0193
      Manidipine 2Hcl (CV-4093) is a dihydropyridine compound and a calcium channel blocker for Ca2+ current with IC50 of 2.6 nM. MedChem Express http://www.medchemexpress.com/carboplatin.html, HY-17403
      Manidipine 2Hcl (CV-4093) is a dihydropyridine compound and a calcium channel blocker for Ca2+ current with IC50 of 2.6 nM. ;IC50 value: 2.6 nM;Target: calcium channelManidipine is described to block T-type Ca2+ channels specifically and is also described to have a high selectivity for the vasculature, presenting negligible cardiodepression as compared to other Ca2+ channel antagonists. Manidipine is also described to not significantly affect norepinephrine levels, suggesting a lack of sympathetic activation with this compound. Manidipine reduces pro-inflammatory cytokines secretion in human endothelial cells and macrophages. Manidipine, unlike other third-generation dihydropyridine derived drugs, blocks T-type calcium channels present in the efferent glomerular arterioles, reducing intraglomerular pressure and microalbuminuria. MedChem Express HY-17403
      Membrane Transporter/Ion Channel MedChem Express HY-17403
      Membrane Transporter/Ion Channel TargetMol T0193
      Membrane Transporter/Ion Channel; MedChem Express HY-17403

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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