ChemSpider 2D Image | DD6730000 | C19H21Cl2N3

DD6730000

  • Molecular FormulaC19H21Cl2N3
  • Average mass362.296 Da
  • Monoisotopic mass361.111267 Da
  • ChemSpider ID13766

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1-(4-Chlorbenzyl)-2-(1-pyrrolidinylmethyl)-1H-benzimidazolhydrochlorid (1:1) [German] [ACD/IUPAC Name]
1-(4-Chlorobenzyl)-2-(1-pyrrolidinylmethyl)-1H-benzimidazole hydrochloride (1:1) [ACD/IUPAC Name]
1-(4-Chlorobenzyl)-2-(1-pyrrolidinylméthyl)-1H-benzimidazole, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
1-(4-Chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)-1H-benzimidazole hydrochloride (1:1)
1-(p-Chlorobenzyl)-2-(1-pyrrolidinylmethyl)benzimidazole hydrochloride
1-(p-Chlorobenzyl)-2-pyrrolidylmethylenebenzimidazole hydrochloride
1-[(4-Chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-1H-benzimidazole hydrochloride
1-[(4-chlorophenyl)methyl]-2-[(pyrrolidin-1-yl)methyl]-1H-1,3-benzodiazole hydrochloride
1163-36-6 [RN]
1H-Benzimidazole, 1-[(4-chlorophenyl)methyl]-2-(1-pyrrolidinylmethyl)-, hydrochloride (1:1) [ACD/Index Name]
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

85W6I13D8M [DBID]
AL 20 [DBID]
C5040_SIGMA [DBID]
D01705 [DBID]
EU-0100284 [DBID]
MLS000028396 [DBID]
MLS000120342 [DBID]
Prestwick_116 [DBID]
SMR000058430 [DBID]
UNII:85W6I13D8M [DBID]
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  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      Histamine Receptor TargetMol T1822L

    • Therapeutical Effect:

      H1-antihistamine Rudolf Boehm Institute [01505990]

    • Compound Source:

      synthetic; AL-20 Rudolf Boehm Institute [01505990]

    • Bio Activity:

      Clemizole Hcl is a H1 histamine receptor antagonist. MedChem Express http://www.medchemexpress.com/cot-inhibitor-1.html, HY-30234A
      Clemizole Hcl is a H1 histamine receptor antagonist. Recently, researchers have identified that clemizole hydrochloride can inhibit NS4B's RNA binding and hepatitis C virus (HCV) replication.;IC50 Value: 8mM (NS4B) [1];Target: H1 receptor; Anti-HCV;In vitro: Although significant, clemizole's antiviral effect is moderate (50% effective concentration of 8 microM against an HCV genotype 2a clone). Combinations of clemizole with either interferon, ribavirin, or the nucleoside (NM283) and nonnucleoside (HCV796) HCV polymerase inhibitors were additive [1]. The differences in the rodent and human pathways for clemizole metabolism were of importance, because the predominant human metabolite was found to have synergistic anti-HCV activity [2].;In vivo: Clemizole and reserpine treatment did not produce any modification of the dose-response curve to histamine [3].Clinical trial: Safety and Tolerability Study of Clemizole Hydrochloride to Treat Hepatitis C in Subjects Who Are Treatment-Naiv MedChem Express HY-30234A
      GPCR/G protein MedChem Express HY-30234A
      GPCR/G protein; MedChem Express HY-30234A
      H1 receptor TargetMol T1822L
      Histamine Receptor MedChem Express HY-30234A
      Ion Channels Tocris Bioscience 5371
      Neuroscience TargetMol T1822L
      Transient Receptor Potential Channels Tocris Bioscience 5371
      TRPC Tocris Bioscience 5371
      TRPC5 blocker; also H1 antagonist Tocris Bioscience 5371
      TRPC5 channel blocker (IC50 values are 1.1, 6.4, 9.1, 11.3 and 26.5 ?M for TRPC5, TRPC4, TRPC3, TRPC6 and TRPC7 respectively). Exhibits minimal effect on TRPM3, TRPM8 and TRPV1-4 channels. Also histam ine H1 receptor antagonist and anticonvulsant in zebrafish Dravet syndrome model. Tocris Bioscience 5371
      TRPC5 channel blocker (IC50 values are 1.1, 6.4, 9.1, 11.3 and 26.5 ?M for TRPC5, TRPC4, TRPC3, TRPC6 and TRPC7 respectively). Exhibits minimal effect on TRPM3, TRPM8 and TRPV1-4 channels. Also histamine H1 receptor antagonist and anticonvulsant in zebrafish Dravet syndrome model. Tocris Bioscience 5371
      TRPC5 channel blocker (IC50 values are 1.1, 6.4, 9.1, 11.3 and 26.5 muM for TRPC5, TRPC4, TRPC3, TRPC6 and TRPC7 respectively). Exhibits minimal effect on TRPM3, TRPM8 and TRPV1-4 channels. Also histamine H1 receptor antagonist and anticonvulsant in zebrafish Dravet syndrome model. Tocris Bioscience 5371

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

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