ChemSpider 2D Image | Canertinib dihydrochloride | C24H27Cl3FN5O3

Canertinib dihydrochloride

  • Molecular FormulaC24H27Cl3FN5O3
  • Average mass558.860 Da
  • Monoisotopic mass557.116333 Da
  • ChemSpider ID137740

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

289499-45-2 [RN]
2-Propenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-, hydrochloride (1:2) [ACD/Index Name]
Canertinib HCl
Canertinib (hydrochloride)
Canertinib dihydrochloride [USAN]
ICJ93X8X90
MFCD09954112 [MDL number]
N-[4-(3-Chloro-4-fluorophenylamino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]acrylamide dihydrochloride
N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide dihydrochloride
N-{4-[(3-Chlor-4-fluorphenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-chinazolinyl}acrylamiddihydrochlorid [German] [ACD/IUPAC Name]
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

CI-1033 [DBID]
PD-0183805 [DBID]
PD-183805 [DBID]
CI 1033 [DBID]
CI1033 [DBID]
D03350 [DBID]
PD 183805 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Safety:

      Sold for research purposes under agreement from Pfizer Inc. Tocris Bioscience 5916

    • Target Organs:

      EGFR inhibitor; HER2 inhibitor TargetMol T2501

    • Bio Activity:

      Canertinib 2Hcl (CI-1033; PD-183805) is a pan-ErbB inhibitor for EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM, no activity to PDGFR, FGFR, InsR, PKC, or CDK1/2/4. MedChem Express
      Canertinib 2Hcl (CI-1033; PD-183805) is a pan-ErbB inhibitor for EGFR and ErbB2 with IC50 of 1.5 nM and 9.0 nM, no activity to PDGFR, FGFR, InsR, PKC, or CDK1/2/4.; IC50 value: 1.5/0.9 nM(EGFR/ErbB2) [1]; Target: EGFR/ErbB2; in vitro: CI-1033 shows excellent potency for irreversible inhibition of erbB2 autophosphorylation in MDA-MB 453 cells. MedChem Express HY-10367A
      EGFR Tocris Bioscience 5916
      EGFR MedChem Express HY-10367A
      EGFR, ErbB2 TargetMol T2501
      Enzyme-Linked Receptors Tocris Bioscience 5916
      JAK/STAT Signaling MedChem Express HY-10367A
      JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; MedChem Express HY-10367A
      Potent EGFR kinase inhibitor Tocris Bioscience 5916
      Potent EGFR kinase inhibitor (IC50 = 7.4 nM). Blocks autophosphorylation of erbB2. Inhibits growth of A431 tumor xenografts in mice. Cell permeable. Tocris Bioscience 5916
      Receptor Tyrosine Kinases (RTKs) Tocris Bioscience 5916
      Tyrosine Kinase/Adaptors TargetMol T2501

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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