ChemSpider 2D Image | Fasudil Hydrochloride | C14H18ClN3O2S

Fasudil Hydrochloride

  • Molecular FormulaC14H18ClN3O2S
  • Average mass327.830 Da
  • Monoisotopic mass327.080811 Da
  • ChemSpider ID143622

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

Fasudil Hydrochloride
105628-07-7 [RN]
5-(1,4-Diazepan-1-ylsulfonyl)isochinolinhydrochlorid (1:1) [German] [ACD/IUPAC Name]
5-(1,4-Diazépan-1-ylsulfonyl)isoquinoléine, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
5-(1,4-Diazepan-1-ylsulfonyl)isoquinoline hydrochloride (1:1) [ACD/IUPAC Name]
Eril [Trade name]
Fasudil HCl
Fasudil Hydrochloride
Fasudil hydrochloride (JAN) [JAN]
Fasudil Monohydrochloride
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

AT 877 [DBID]
HA 1077 [DBID]
AT-877 [DBID]
D01840 [DBID]
HA-1077 [DBID]
MLS000069344 [DBID]
PubChem Substance ID 24851494 [DBID]
SMR000058993 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      ROCK inhibitor TargetMol T3060

    • Chemical Class:

      A hydrochloride obtained by reaction of fasudil with one equivalent of hydrochloric acid. ChEBI CHEBI:31593

    • Bio Activity:

      Biochemicals & small molecules/Antagonists & inhibitors Hello Bio HB0283
      Cell Cycle/Checkpoint TargetMol T3060
      Cell Cycle/DNA Damage MedChem Express HY-10341
      Cell Cycle/DNA Damage; TGF-beta/Smad; MedChem Express HY-10341
      Cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC50 = 10.7 ?M). Suppress MMP-2 expression and induce apoptosis in glioblastoma cells in vivo. Ca2+ antagonist and vasodilator. Also inhibits proliferation of vascular smooth muscle cells. Tocris Bioscience 541
      Cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC50 = 10.7 ?M). Suppress MMP-2 expression and induce apoptosis in glioblastoma cells in vivo. Ca2+ antagonist and vasodilator. Also inhibits proliferation of vascular smooth muscle cells. Tocris Bioscience 0541
      Cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC50 = 10.7 muM). Suppress MMP-2 expression and induce apoptosis in glioblastoma cells in vivo. Ca2+ antagonist and vasodilator. Also inhibits proliferation of vascular smooth muscle cells. Tocris Bioscience 541
      Enzymes Tocris Bioscience 541
      Enzymes/Kinase/ROCK Hello Bio HB0283
      Fasudil Hcl(HA-1077; AT-877) is a potent inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with Ki of 0.33 ?M, 1.6 ?M, 1.6 ?M, 3.3 ?M and 36 ?M, respectively. MedChem Express HY-10341
      Inhibitor of cyclic nucleotide dependent- and Rho-kinases Tocris Bioscience 0541, 541
      Kinases Tocris Bioscience 541
      PKC ROCK MedChem Express HY-10341
      Rho-associated kinase inhibitor (IC<sub>50</sub> = 10.7 ô‘M) and cyclic nucleotide-dependent protein kinase inhibitor. Inhibits NOS in microglia and pro-inflammatory factors in brain tissue. Also reducesô˜nitric oxide, IL-1žì, IL-6 and TNF. Shows antioxidant effects which can reverse hypertension and neuroprotective actions. Hello Bio HB0283
      Rho-associated kinase inhibitor (IC<sub>50</sub> = 10.7 µM) and cyclic nucleotide-dependent protein kinase inhibitor. Inhibits NOS in microglia and pro-inflammatory factors in brain tissue. Also reduces nitric oxide, IL-1?, IL-6 and TNF. Shows antioxidant effects which can reverse hypertension and neuroprotective actions. Hello Bio HB0283
      Rho-kinases Tocris Bioscience 541
      ROCK MedChem Express HY-10341
      ROCK and cyclic nucleotide-dependent protein kinase inhibitor Hello Bio HB0283
      ROCK-II; PKA; PKG; PKC; MLCK TargetMol T3060

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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