ChemSpider 2D Image | Alogliptin benzoate | C25H27N5O4

Alogliptin benzoate

  • Molecular FormulaC25H27N5O4
  • Average mass461.513 Da
  • Monoisotopic mass461.206299 Da
  • ChemSpider ID17246652

  • defined stereocentres - 1 of 1 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

2-({6-[(3R)-3-Amino-1-piperidinyl]-3-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl}methyl)benzonitrilbenzoat (1:1) [German] [ACD/IUPAC Name]
2-({6-[(3R)-3-Amino-1-piperidinyl]-3-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl}methyl)benzonitrile benzoate (1:1) [ACD/IUPAC Name]
2-({6-[(3R)-3-Amino-1-pipéridinyl]-3-méthyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl}méthyl)benzonitrile benzoate (1:1) [French] [ACD/IUPAC Name]
2-({6-[(3R)-3-Aminopiperidin-1-yl]-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl}methyl)benzonitrile benzoate (1:1)
850649-62-6 [RN]
Alogliptin (benzoate salt)
Alogliptin benzoate [USAN]
Benzonitrile, 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-, benzoate (1:1) [ACD/Index Name]
(3R)-1-[3-(2-cyanobenzyl)-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl]piperidin-3-aminium benzoate; 2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl}methyl)b
(3R)-1-[3-(2-cyanobenzyl)-1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl]piperidin-3-aminium benzoate; 2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl}methyl)benzonitrile benzoate
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

SYR-322 [DBID]
SYR 322 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      DPP-4 inhibitor TargetMol T2401

    • Chemical Class:

      A benzoate salt obtained by combining equimolar amounts of alogliptin and benzoic acid. Used for treatment of type 2 diabetes. ChEBI https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:72324, CHEBI:72324

    • Bio Activity:

      Alogliptin benzoate(SYR 322) is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9. MedChem Express
      Alogliptin benzoate(SYR 322) is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.;IC50 value: <10 nM;Target: DPP4Alogliptin is an orally administered, anti-diabetic drug in the DPP-4 inhibitor class. A randomized clinical trial reporting in 2011 aimed to determine the efficacy and safety of alogliptin versus placebo and voglibose among newly diagnosed Type 2 diabetes patients in Japan. The main outcome indicated that alogliptin was statistically superior to both comparitors. A randomized clinical trial reporting in 2012 aimed to demonstrate that alogliptin was non-inferior to a very low fat/calorie traditional Japanese diet among newly diagnosed Type 2 diabetes patients in Japan. The outcome indicated that both the drug and dietary treatments comparably impacted indicators of the diabetic condition, such as HbA1c levels and glycemic efficacy. The drug treatment had its impact without changing body ma MedChem Express HY-A0023
      DPP4 MedChem Express HY-A0023
      DPP-4 TargetMol T2401
      Metabolism/Protease; MedChem Express HY-A0023
      Proteases/Proteasome TargetMol T2401

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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