ChemSpider 2D Image | Otenabant hydrochloride | C25H26Cl3N7O

Otenabant hydrochloride

  • Molecular FormulaC25H26Cl3N7O
  • Average mass546.879 Da
  • Monoisotopic mass545.126465 Da
  • ChemSpider ID17351202

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1-[8-(2-Chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-(ethylamino)-4-piperidinecarboxamide hydrochloride (1:1) [ACD/IUPAC Name]
1-[8-(2-Chlorophényl)-9-(4-chlorophényl)-9H-purin-6-yl]-4-(éthylamino)-4-pipéridinecarboxamide, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
1-[8-(2-Chlorphenyl)-9-(4-chlorphenyl)-9H-purin-6-yl]-4-(ethylamino)-4-piperidincarboxamidhydrochlorid (1:1) [German] [ACD/IUPAC Name]
4-Piperidinecarboxamide, 1-[8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl]-4-(ethylamino)-, hydrochloride (1:1) [ACD/Index Name]
686347-12-6 [RN]
CP 945,598 (hydrochloride)
Otenabant HCl
Otenabant hydrochloride [USAN]
X2166Z319O
(3-Chloropyrazin-2-yl)-(oxolan-3-yl)methanone
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

CP-945,598 [DBID]
CP 945598 hydrochloride [DBID]
CP-945598 [DBID]
CP-945598 HCl [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Safety:

      Sold for research purposes under agreement from Pfizer Inc. Tocris Bioscience 4236

    • Target Organs:

      Cannabinoid Receptor antagonist TargetMol T1796

    • Bio Activity:

      7-TM Receptors Tocris Bioscience 4236
      Cannabinoid Receptor MedChem Express HY-10871A
      Cannabinoid Receptors Tocris Bioscience 4236
      CB1 receptor TargetMol T1796
      CB1 receptor antagonist Tocris Bioscience 4236
      CB1 Receptors Tocris Bioscience 4236
      GPCR/G protein MedChem Express HY-10871A
      GPCR/G Protein TargetMol T1796
      GPCR/G protein; MedChem Express HY-10871A
      Otenabant Hcl (CP-945598) is a recently discovered selective, high affinity, competitive CB1 receptor antagonist with Ki of 0.7 nM. MedChem Express http://www.medchemexpress.com/N-Desethyl-Sunitinib.html, HY-10871A
      Otenabant Hcl (CP-945598) is a recently discovered selective, high affinity, competitive CB1 receptor antagonist with Ki of 0.7 nM. ;IC50 Value: 0.7 nM(Ki for binding)/0.2 nM (Ki for function) [1];Target: CB1 receptor;In vitro : Otenabant (CP-945,598) exhibits sub-nanomolar potency at human CB1 receptors in both binding (Ki = 0.7 nM) and functional assays (Ki = 0.2 nM). The compound has low affinity (Ki = 7600 nM) for human CB2 receptors[1];In vivo: Otenabant (CP-945,598) reverses four cannabinoid agonist-mediated CNS-driven responses (hypo-locomotion, hypothermia, analgesia, and catalepsy) to a synthetic cannabinoid receptor agonist. Otenabant (CP-945,598) exhibits dose and concentration-dependent anorectic activity in two models of acute food intake in rodents, fast-induced re-feeding and spontaneous, nocturnal feeding. Otenabant (CP-945,598) also acutely stimulates energy expenditure in rats and decreases the respiratory quotient indicating a metabolic switch to increased fat o MedChem Express HY-10871A
      Selective, high affinity CB1 antagonist (Ki values are 0.7 and 0.12 nM in binding and functional assays respectively). Displays low affinity for CB2 receptors (Ki = 7600 nM). Tocris Bioscience 4236

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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