ChemSpider 2D Image | Alverine citrate | C26H35NO7

Alverine citrate

  • Molecular FormulaC26H35NO7
  • Average mass473.559 Da
  • Monoisotopic mass473.241364 Da
  • ChemSpider ID20413

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

226-929-3 [EINECS]
2-Hydroxy-1,2,3-propantricarbonsäure --N-ethyl-3-phenyl-N-(3-phenylpropyl)-1-propanamin (1:1) [German] [ACD/IUPAC Name]
2-hydroxypropane-1,2,3-tricarboxylic acid; ethylbis(3-phenylpropyl)amine
5560-59-8 [RN]
9JFB58YK1E
Acide 2-hydroxy-1,2,3-propanetricarboxylique - N-éthyl-3-phényl-N-(3-phénylpropyl)-1-propanamine (1:1) [French] [ACD/IUPAC Name]
Alverine (citrate)
Alverine citrate [USAN]
Alverine citrate salt
Benzenepropanamine, N-ethyl-N-(3-phenylpropyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (salt) [ACD/Index Name]
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

NSC 35459 [DBID]
3851428 [DBID]
A0424_SIGMA [DBID]
D02877 [DBID]
MLS000069524 [DBID]
NCGC00017047-01 [DBID]
NSC35459 [DBID]
Prestwick_912 [DBID]
SMR000058631 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Safety:

      A03AX08 Wikidata Q27124210

    • Target Organs:

      5-HT Receptor antagonist TargetMol T0428

    • Chemical Class:

      The citrate salt of alverine, resulting from the reaction of equimolar amounts of alvarine and citric acid. An antispasmodic that acts directly on intestinal and uterine smooth muscle, it is used in t he treatment of irritable bowel syndrome. ChEBI https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:53785, CHEBI:53785

    • Bio Activity:

      5-HT Receptor MedChem Express HY-B0500
      5-HT Receptor TargetMol T0428
      Alverine Citrate(NSC35459) is a drug used for functional gastrointestinal disorders. MedChem Express
      Alverine Citrate(NSC35459) is a drug used for functional gastrointestinal disorders.; Target: 5-HT Receptor; Alverine is a drug used for functional gastrointestinal disorders. MedChem Express HY-B0500
      Alverine Citrate(NSC35459) is a drug used for functional gastrointestinal disorders.;Target: 5-HT ReceptorAlverine is a drug used for functional gastrointestinal disorders. Alverine acts directly on the muscle in the gut, causing it to relax. Alverine Citrate (20 mg kg(-1)) suppressed the effect of 5-HTP, but not that of 8-OH-DPAT. However, when injected intracerebroventricularly (75 microg/rat) alverine citrate reduced 8-OH-DPAT-induced enhancement of rectal distension-induced abdominal contractions. In-vitro binding studies revealed that alverine citrate had a high affinity for 5-HT1A receptors and a weak affinity for 5-HT3 and 5-HT4 subtypes [1]. Alverine may increase Ca influx during action potentials due to inhibition of the inactivation of L-type Ca channels, but may also suppress evoked activity by inhibiting the sensitivity of contractile proteins to Ca2+ [2]. MedChem Express HY-B0500
      GPCR/G protein MedChem Express HY-B0500
      GPCR/G protein; Neuronal Signaling; MedChem Express HY-B0500
      Neuroscience TargetMol T0428

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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