ChemSpider 2D Image | CCT128930 | C18H20ClN5

CCT128930

  • Molecular FormulaC18H20ClN5
  • Average mass341.838 Da
  • Monoisotopic mass341.140717 Da
  • ChemSpider ID23317247

More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

4-(4-Chlorbenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinamin [German] [ACD/IUPAC Name]
4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinamine [ACD/IUPAC Name]
4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-pipéridinamine [French] [ACD/IUPAC Name]
4-(4-chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-amine
4-piperidinamine, 4-[(4-chlorophenyl)methyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)- [ACD/Index Name]
885499-61-6 [RN]
CCT128930
[885499-61-6]
1,2,4-Thiadiazol-3-amine [ACD/Index Name] [ACD/IUPAC Name]
4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-
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  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Safety:

      Harmful/Irritant SynQuest 3H30-5-01
    • Bio Activity:

      Akt MedChem Express HY-13260
      CCT128930 is a novel potent ATP-competitive, selective Akt2 inhibitor with an IC50 of 6 nM; >28-fold selectivity for Akt2 than the closely related PKA kinase.; IC50 value: 0.6 nM; Target: Akt2; CCT128930 prevents AKT activity in vitro and in vivo and induces marked antitumor responses. MedChem Express HY-13260
      CCT128930 is a novel potent ATP-competitive, selective Akt2 inhibitor with an IC50 of 6 nM; >28-fold selectivity for Akt2 than the closely related PKA kinase.;IC50 value: 0.6 nM;Target: Akt2CCT128930 prevents AKT activity in vitro and in vivo and induces marked antitumor responses. CCT128930 showed significantly antiproliferative activity and inhibited the phosphorylation of a range of AKT substrates in multiple tumor cell lines in vitro, consistent with AKT inhibition. CCT128930 caused a G1 arrest in PTEN-null U87MG human glioblastoma cells, in good agreement with AKT pathway blockade. MedChem Express HY-13260
      PI3K/Akt/mTOR MedChem Express HY-13260
      PI3K/Akt/mTOR; MedChem Express HY-13260

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.3±0.1 g/cm3
Boiling Point: 547.9±50.0 °C at 760 mmHg
Vapour Pressure: 0.0±1.5 mmHg at 25°C
Enthalpy of Vaporization: 82.7±3.0 kJ/mol
Flash Point: 285.2±30.1 °C
Index of Refraction: 1.680
Molar Refractivity: 97.0±0.3 cm3
#H bond acceptors: 5
#H bond donors: 3
#Freely Rotating Bonds: 3
#Rule of 5 Violations: 0
ACD/LogP: 2.93
ACD/LogD (pH 5.5): -0.67
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 1.00
ACD/LogD (pH 7.4): 1.51
ACD/BCF (pH 7.4): 3.93
ACD/KOC (pH 7.4): 38.06
Polar Surface Area: 71 Å2
Polarizability: 38.5±0.5 10-24cm3
Surface Tension: 67.2±3.0 dyne/cm
Molar Volume: 256.8±3.0 cm3

Click to predict properties on the Chemicalize site






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