ChemSpider 2D Image | SNS-314 Mesylate | C19H19ClN6O4S3

SNS-314 Mesylate

  • Molecular FormulaC19H19ClN6O4S3
  • Average mass527.040 Da
  • Monoisotopic mass526.031860 Da
  • ChemSpider ID23335848

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1-(3-chlorophenyl)-3-[5-(2-{thieno[3,2-d]pyrimidin-4-ylamino}ethyl)-1,3-thiazol-2-yl]urea; methanesulfonic acid
1-(3-chlorophenyl)-3-{5-[2-({thieno[3,2-d]pyrimidin-4-yl}amino)ethyl]-1,3-thiazol-2-yl}urea; methanesulfonic acid
1-(3-Chlorophenyl)-3-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}urea methanesulfonate (1:1) [ACD/IUPAC Name]
1146618-41-8 [RN]
Acide méthanesulfonique - 1-(3-chlorophényl)-3-{5-[2-(thiéno[3,2-d]pyrimidin-4-ylamino)éthyl]-1,3-thiazol-2-yl}urée (1:1) [French] [ACD/IUPAC Name]
Methansulfonsäure --1-(3-chlorphenyl)-3-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}harnstoff (1:1) [German] [ACD/IUPAC Name]
SNS-314 (mesylate)
SNS-314 Mesylate
Urea, N-(3-chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]-, methanesulfonate (1:1) [ACD/Index Name]
[1146618-41-8] [RN]
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

KGW32FDY3U [DBID]
CCRIS 4693 [DBID]
UNII:KGW32FDY3U [DBID]
UNII-KGW32FDY3U [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      Aurora Kinase inhibitor TargetMol T2617

    • Bio Activity:

      Aurora C;Aurora A;Aurora B TargetMol T2617
      Aurora Kinase MedChem Express HY-12003
      Aurora Kinases Tocris Bioscience 4584
      Cell Cycle/Checkpoint TargetMol T2617
      Cell Cycle/DNA Damage MedChem Express HY-12003
      Cell Cycle/DNA Damage; MedChem Express HY-12003
      Enzymes Tocris Bioscience 4584
      Kinases Tocris Bioscience 4584
      Potent pan-Aurora kinase inhibitor Tocris Bioscience 4584
      Potent, ATP-competitive Aurora kinase inhibitor (IC50 values are 3, 9 and 31 nM for Aurora C, A and B, respectively). Exhibits both in vitro and in vivo activity against human cancer cell lines and tu mor xenograft models. Displays additive antiproliferative effects in combination with chemotherapeutics such as carboplatin (Cat. No. 2626), gemcitabine (Cat. No. 3259) and 5-fluorouracil (Cat. No. 32 57). Tocris Bioscience 4584
      Potent, ATP-competitive Aurora kinase inhibitor (IC50 values are 3, 9 and 31 nM for Aurora C, A and B, respectively). Exhibits both in vitro and in vivo activity against human cancer cell lines and tumor xenograft models. Displays additive antiproliferative effects in combination with chemotherapeutics such as carboplatin (Cat. No. 2626), gemcitabine (Cat. No. 3259) and 5-fluorouracil (Cat. No. 3257). Tocris Bioscience 4584
      SNS-314 is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively. MedChem Express http://www.medchemexpress.com/sns-314.html, HY-12003
      SNS-314 is a potent and selective inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 9 nM, 31 nM, and 3 nM, respectively. ;IC50 Value: 9.0 nM(Aurora A); 31 nM(Aurora B); 3 nM(Aurora C);Target: pan Aurora Kinase;In vitro: In HCT116 colorectal carcinoma cell line, with intact or depleted p53 protein levels, SNS-314 shows enhanced efficacy when administered sequentially with other standard chemotherapeutic agents and the most profound synergies are identified for agents that activate the spindle assembly checkpoint, e.g., docetaxel and vincristine. A recent study shows that SNS-314 shows potent antiproliferative activity in HCT116 cells and inhibits soft agar colony formation. ;In vivo: The sequential treatment with SNS-314 followed by docetaxel 24 hours later produces a significant 72.5% tumor growth inhibition of HCT116 xenografts, while docetaxel and SNS-314 as single agents produce no significant inhibition of HCT116 tumor growth. In the HCT116 human colon cancer xenograft MedChem Express HY-12003

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

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