ChemSpider 2D Image | Thiazovivin | C15H13N5OS

Thiazovivin

  • Molecular FormulaC15H13N5OS
  • Average mass311.362 Da
  • Monoisotopic mass311.084076 Da
  • ChemSpider ID24597612

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1226056-71-8 [RN]
4-Thiazolecarboxamide, N-(phenylmethyl)-2-(4-pyrimidinylamino)- [ACD/Index Name]
N-Benzyl-2-(4-pyrimidinylamino)-1,3-thiazol-4-carboxamid [German] [ACD/IUPAC Name]
N-Benzyl-2-(4-pyrimidinylamino)-1,3-thiazole-4-carboxamide [ACD/IUPAC Name]
N-Benzyl-2-(4-pyrimidinylamino)-1,3-thiazole-4-carboxamide [French] [ACD/IUPAC Name]
N-Benzyl-2-(pyrimidin-4-ylamino)-1,3-thiazole-4-carboxamide
N-benzyl-2-[(pyrimidin-4-yl)amino]-1,3-thiazole-4-carboxamide
Thiazovivin
[1226056-71-8] [RN]
Benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamide
More...
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      ROCK inhibitor TargetMol T2155

    • Bio Activity:

      <p>Rock inhibitor. When used with <a href="/sb-431542.html" title="SB431542 | Hello Bio" target="_self">SB431542</a> and <a href="/pd-0325901.html" title="PD 0325901 | Hello Bio" target="_self">PD 0325901</a> it enhances efficiency of fibroblast reprogramming to iPSCs. It also improves hESCs survival.</p> Hello Bio HB3240
      Biochemicals & small molecules/Antagonists & inhibitors Hello Bio HB3240
      Cell Biology Tocris Bioscience 3845
      Cell Cycle/Checkpoint TargetMol T2155
      Cell Cycle/DNA Damage MedChem Express HY-13257
      Cell Cycle/DNA Damage; TGF-beta/Smad; MedChem Express HY-13257
      Cell process/Stem cells/Dedifferentiation Hello Bio HB3240
      Greatly enhances the efficiency of fibroblast reprogramming to generate induced pluripotent stem cells (iPSCs) when used in combination with SB 431542 (Cat. No. 1614) and PD 0325901 (Cat. No. 4192). I mproves the survival of human embryonic stem cells (hESCs) upon trypsinization. Tocris Bioscience 3845
      Greatly enhances the efficiency of fibroblast reprogramming to generate induced pluripotent stem cells (iPSCs) when used in combination with SB 431542 (Cat. No. 1614) and PD 0325901 (Cat. No. 4192). Improves the survival of human embryonic stem cells (hESCs) upon trypsinization. Tocris Bioscience 3845
      Improves the efficiency of fibroblast reprogramming and induction of iPSCs Tocris Bioscience 3845
      Reprogramming Tocris Bioscience 3845
      ROCK MedChem Express HY-13257
      ROCK TargetMol T2155
      Rock inhibitor. Improves fibroblast reprogramming efficiency and iPSCs induction. Hello Bio HB3240
      Stem Cells Tocris Bioscience 3845
      Thiazovivin (Tzv) is a novel ROCK inhibitor with IC50 of 0.5 ?M, promotes hESC survival after single-cell dissociation.; IC50 Value: 0.5 ?M; Target: ROCK; in vitro: Thiazovivin treatment significantly enhances the survival of human embryonic stem cells (hESCs) after enzymatic dissociation more than 30-fold, while homogenously maintaining pluripotency with the characteristic colony morphology, expression of typical pluripotency markers such as alkaline phosphatase (ALP), and normal karyotype. MedChem Express HY-13257

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.4±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.691
Molar Refractivity: 86.4±0.3 cm3
#H bond acceptors: 6
#H bond donors: 2
#Freely Rotating Bonds: 5
#Rule of 5 Violations: 0
ACD/LogP: 2.00
ACD/LogD (pH 5.5): 2.06
ACD/BCF (pH 5.5): 21.57
ACD/KOC (pH 5.5): 313.39
ACD/LogD (pH 7.4): 2.06
ACD/BCF (pH 7.4): 21.62
ACD/KOC (pH 7.4): 314.11
Polar Surface Area: 108 Å2
Polarizability: 34.3±0.5 10-24cm3
Surface Tension: 69.5±3.0 dyne/cm
Molar Volume: 225.7±3.0 cm3

Click to predict properties on the Chemicalize site


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