ChemSpider 2D Image | GSK1059615 | C18H11N3O2S

GSK1059615

  • Molecular FormulaC18H11N3O2S
  • Average mass333.364 Da
  • Monoisotopic mass333.057190 Da
  • ChemSpider ID24747368

  • Double-bond stereo - Double-bond stereo

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(5Z)-5-{[4-(4-Pyridinyl)-6-chinolinyl]methylen}-1,3-thiazolidin-2,4-dion [German] [ACD/IUPAC Name]
(5Z)-5-{[4-(4-Pyridinyl)-6-quinoléinyl]méthylène}-1,3-thiazolidine-2,4-dione [French] [ACD/IUPAC Name]
(5Z)-5-{[4-(4-Pyridinyl)-6-quinolinyl]methylene}-1,3-thiazolidine-2,4-dione [ACD/IUPAC Name]
2,4-Thiazolidinedione, 5-[[4-(4-pyridinyl)-6-quinolinyl]methylene]-, (5Z)- [ACD/Index Name]
958852-01-2 [RN]
GSK1059615
GSK-1059615
(5Z)-5-[(4-pyridin-4-ylquinolin-6-yl)methylidene]-1,3-thiazolidine-2,4-dione
(5Z)-5-[[4-(4-pyridyl)-6-quinolyl]methylene]thiazolidine-2,4-dione
(5Z)-5-[[4-(4-pyridyl)-6-quinolyl]methylene]thiazolidine-2,4-quinone
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

07YMO87363 [DBID]
UN2811 [DBID]
UNII:07YMO87363 [DBID]
UNII-07YMO87363 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Safety:

      Sold for research purposes under agreement from GlaxoSmithKline Tocris Bioscience 4026

    • Bio Activity:

      Enzymes Tocris Bioscience 4026
      GSK1059615 is a dual inhibitor of PI3K?/?/?/? (reversible) and mTOR with IC50 of 0.4 nM/0.6 nM/2 nM/5 nM and 12 nM, respectively.; IC50 value: 0.4 nM/0.6 nM/2 nM/5 nM(PI3K?/?/?/?); 12 nM (mTOR) [1]; Target: PI3K; mTOR; in vitro: The pyridinylquinoline derivative GSK1059615 is a novel, ATP-competitive, and reversible inhibitor of the class I family of PI3Ks. MedChem Express HY-12036
      Kinases Tocris Bioscience 4026
      mTOR MedChem Express HY-12036
      mTOR PI3K MedChem Express HY-12036
      PI 3-Kinase Tocris Bioscience 4026
      PI3K/Akt/mTOR MedChem Express HY-12036
      PI3K/Akt/mTOR ; MedChem Express HY-12036
      Potent inhibitor of PI 3-kinase ? (PI3K?) (IC50 = 2 nM). Inhibits proliferation in BT474 cells and attenuates MAPK signaling. Tocris Bioscience 4026
      Potent inhibitor of PI 3-kinase alpha (PI3Kalpha) (IC50 = 2 nM). Inhibits proliferation in BT474 cells and attenuates MAPK signaling. Tocris Bioscience 4026
      Potent PI 3-kinase inhibitor Tocris Bioscience 4026

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.4±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.759
Molar Refractivity: 94.9±0.3 cm3
#H bond acceptors: 5
#H bond donors: 1
#Freely Rotating Bonds: 2
#Rule of 5 Violations: 0
ACD/LogP: 1.78
ACD/LogD (pH 5.5): 1.86
ACD/BCF (pH 5.5): 15.07
ACD/KOC (pH 5.5): 241.27
ACD/LogD (pH 7.4): 1.47
ACD/BCF (pH 7.4): 6.25
ACD/KOC (pH 7.4): 100.03
Polar Surface Area: 97 Å2
Polarizability: 37.6±0.5 10-24cm3
Surface Tension: 74.1±3.0 dyne/cm
Molar Volume: 230.9±3.0 cm3

Click to predict properties on the Chemicalize site


Advertisement