ChemSpider 2D Image | CCCP | C9H5ClN4


  • Molecular FormulaC9H5ClN4
  • Average mass204.616 Da
  • Monoisotopic mass204.020279 Da
  • ChemSpider ID2504

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

[(3-Chlorophenyl)hydrazono]malononitrile [ACD/IUPAC Name]
[(3-Chlorophényl)hydrazono]malononitrile [French] [ACD/IUPAC Name]
[(3-Chlorphenyl)hydrazono]malononitril [German] [ACD/IUPAC Name]
209-103-7 [EINECS]
555-60-2 [RN]
Carbonyl cyanide (m-chlorophenyl)hydrazone
Carbonyl cyanide 3-chlorophenylhydrazone

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

FG5600000 [DBID]
AIDS097715 [DBID]
AIDS-097715 [DBID]
BRN 1842102 [DBID]
C11164 [DBID]
D002258 [DBID]
MolMap_000008 [DBID]
nchembio.94-comp27 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Toxicity:

      Organic Compound; Organochloride; Aromatic Hydrocarbon; Cyanide Compound; Nitrile; Hydrazine; Pollutant; Industrial/Workplace Toxin; Synthetic Compound Toxin, Toxin-Target Database T3D1697
    • Safety:

      20-26-36/37-45-60 Alfa Aesar L06932
      25-36/37/38 Alfa Aesar L06932
      36/37-45 Alfa Aesar L06932
      6.1 Alfa Aesar L06932
      Danger Alfa Aesar L06932
      DANGER: POISON, causes cyanosis; skin, eye, lung irritation Alfa Aesar L06932
      H301-H315-H319-H335 Alfa Aesar L06932
      P261-P280-P301+P310-P305+P351+P338-P405-P501a Alfa Aesar L06932
      TOXIC Alfa Aesar L06932
    • Chemical Class:

      A member of the class of monochlorobenzenes that is benzene substituted by 2-(1,3-dinitrilopropan-2-ylidene)hydrazinyl and chloro groups at positions 1 and 3, respectively. It is a mitochondrial depol arizing agent that induces reactive oxygen species mediated cell death. ChEBI CHEBI:3259
    • Bio Activity:

      <p>CCCP is a protonophore which is a widely used uncoupler of mitochondrial oxidative phosphorylation.</p> <p><br />CCCP disrupts ATP synthesis by transporting protons across the mitochondrial inner membrane, interfering with the proton gradient.</p> <p>By depolarizing the plasma membrane and reducing ATP production, CCCP can indirectly affect proton pump activity and cellular metabolism to cause cell death.</p> <p><br />The uncoupling agent <a href=/fccp.html title=FCCP | Uncoupling agent | Hello Bio target=_self>FCCP </a>is also available.</p> Hello Bio [HB5062]
      Cell Biology Tocris Bioscience 452
      Cell Metabolism Tocris Bioscience 452
      Cell process/Oxidative Phosphorylation Hello Bio [HB5062]
      Oxidative Phosphorylation Tocris Bioscience 452
      Oxidative phosphorylation uncoupler Tocris Bioscience 0452, 452
      Potent uncoupler of mitochondrial oxidative phosphorylation Hello Bio [HB5062]
      Widely used uncoupler of oxidative phosphorylation. Tocris Bioscience 0452, 452
  • Gas Chromatography

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.3±0.1 g/cm3
Boiling Point: 318.3±44.0 °C at 760 mmHg
Vapour Pressure: 0.0±0.7 mmHg at 25°C
Enthalpy of Vaporization: 56.0±3.0 kJ/mol
Flash Point: 146.3±28.4 °C
Index of Refraction: 1.611
Molar Refractivity: 56.0±0.5 cm3
#H bond acceptors: 4
#H bond donors: 1
#Freely Rotating Bonds: 4
#Rule of 5 Violations: 0
ACD/LogP: 3.09
ACD/LogD (pH 5.5): 3.11
ACD/BCF (pH 5.5): 127.71
ACD/KOC (pH 5.5): 1036.63
ACD/LogD (pH 7.4): 1.91
ACD/BCF (pH 7.4): 8.01
ACD/KOC (pH 7.4): 65.04
Polar Surface Area: 72 Å2
Polarizability: 22.2±0.5 10-24cm3
Surface Tension: 50.4±7.0 dyne/cm
Molar Volume: 161.3±7.0 cm3

Predicted data is generated using the US Environmental Protection Agency�s EPISuite™

 Log Octanol-Water Partition Coef (SRC):
    Log Kow (KOWWIN v1.67 estimate) =  3.15
    Log Kow (Exper. database match) =  3.38
       Exper. Ref:  Sturdik,E et al. (1985)

 Boiling Pt, Melting Pt, Vapor Pressure Estimations (MPBPWIN v1.42):
    Boiling Pt (deg C):  368.44  (Adapted Stein & Brown method)
    Melting Pt (deg C):  118.66  (Mean or Weighted MP)
    VP(mm Hg,25 deg C):  1.3E-006  (Modified Grain method)
    MP  (exp database):  176 dec deg C
    Subcooled liquid VP: 4.8E-005 mm Hg (25 deg C, Mod-Grain method)

 Water Solubility Estimate from Log Kow (WSKOW v1.41):
    Water Solubility at 25 deg C (mg/L):  53.8
       log Kow used: 3.38 (expkow database)
       no-melting pt equation used

 Water Sol Estimate from Fragments:
    Wat Sol (v1.01 est) =  2680.7 mg/L

 ECOSAR Class Program (ECOSAR v0.99h):
    Class(es) found:
       Allylic/Vinyl Nitriles

 Henrys Law Constant (25 deg C) [HENRYWIN v3.10]:
   Bond Method :   4.29E-009  atm-m3/mole
   Group Method:   Incomplete
 Henrys LC [VP/WSol estimate using EPI values]:  6.506E-009 atm-m3/mole

 Log Octanol-Air Partition Coefficient (25 deg C) [KOAWIN v1.10]:
  Log Kow used:  3.38  (exp database)
  Log Kaw used:  -6.756  (HenryWin est)
      Log Koa (KOAWIN v1.10 estimate):  10.136
      Log Koa (experimental database):  None

 Probability of Rapid Biodegradation (BIOWIN v4.10):
   Biowin1 (Linear Model)         :   1.0817
   Biowin2 (Non-Linear Model)     :   0.9994
 Expert Survey Biodegradation Results:
   Biowin3 (Ultimate Survey Model):   2.3756  (weeks-months)
   Biowin4 (Primary Survey Model) :   3.2568  (days-weeks  )
 MITI Biodegradation Probability:
   Biowin5 (MITI Linear Model)    :   0.2857
   Biowin6 (MITI Non-Linear Model):   0.0659
 Anaerobic Biodegradation Probability:
   Biowin7 (Anaerobic Linear Model):  0.0521
 Ready Biodegradability Prediction:   NO

Hydrocarbon Biodegradation (BioHCwin v1.01):
    Structure incompatible with current estimation method!

 Sorption to aerosols (25 Dec C)[AEROWIN v1.00]:
  Vapor pressure (liquid/subcooled):  0.0064 Pa (4.8E-005 mm Hg)
  Log Koa (Koawin est  ): 10.136
   Kp (particle/gas partition coef. (m3/ug)):
       Mackay model           :  0.000469 
       Octanol/air (Koa) model:  0.00336 
   Fraction sorbed to airborne particulates (phi):
       Junge-Pankow model     :  0.0166 
       Mackay model           :  0.0361 
       Octanol/air (Koa) model:  0.212 

 Atmospheric Oxidation (25 deg C) [AopWin v1.92]:
   Hydroxyl Radicals Reaction:
      OVERALL OH Rate Constant =  30.0082 E-12 cm3/molecule-sec
      Half-Life =     0.356 Days (12-hr day; 1.5E6 OH/cm3)
      Half-Life =     4.277 Hrs
   Ozone Reaction:
      No Ozone Reaction Estimation
   Fraction sorbed to airborne particulates (phi): 0.0264 (Junge,Mackay)
    Note: the sorbed fraction may be resistant to atmospheric oxidation

 Soil Adsorption Coefficient (PCKOCWIN v1.66):
      Koc    :  521.5
      Log Koc:  2.717 

 Aqueous Base/Acid-Catalyzed Hydrolysis (25 deg C) [HYDROWIN v1.67]:
    Rate constants can NOT be estimated for this structure!

 Bioaccumulation Estimates from Log Kow (BCFWIN v2.17):
   Log BCF from regression-based method = 1.903 (BCF = 79.91)
       log Kow used: 3.38 (expkow database)

 Volatilization from Water:
    Henry LC:  4.29E-009 atm-m3/mole  (estimated by Bond SAR Method)
    Half-Life from Model River: 1.952E+005  hours   (8134 days)
    Half-Life from Model Lake :  2.13E+006  hours   (8.874E+004 days)

 Removal In Wastewater Treatment:
    Total removal:              10.58  percent
    Total biodegradation:        0.16  percent
    Total sludge adsorption:    10.41  percent
    Total to Air:                0.00  percent
      (using 10000 hr Bio P,A,S)

 Level III Fugacity Model:
           Mass Amount    Half-Life    Emissions
            (percent)        (hr)       (kg/hr)
   Air       0.0312          8.55         1000       
   Water     12.4            900          1000       
   Soil      86.9            1.8e+003     1000       
   Sediment  0.677           8.1e+003     0          
     Persistence Time: 1.72e+003 hr


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