ChemSpider 2D Image | cabozantinib (S)-malate | C32H30FN3O10

cabozantinib (S)-malate

  • Molecular FormulaC32H30FN3O10
  • Average mass635.593 Da
  • Monoisotopic mass635.191528 Da
  • ChemSpider ID25948203

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

cabozantinib (S)-malate [USAN]
(2S)-2-Hydroxybernsteinsäure --N-{4-[(6,7-dimethoxy-4-chinolinyl)oxy]phenyl}-N'-(4-fluorphenyl)-1,1-cyclopropandicarboxamid (1:1) [German] [ACD/IUPAC Name]
(2S)-2-hydroxybutanedioic acid; N'1-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N1-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
(2S)-2-Hydroxysuccinic acid - N-{4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl}-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1) [ACD/IUPAC Name]
1140909-48-3 [RN]
Acide (2S)-2-hydroxysuccinique - N-{4-[(6,7-diméthoxy-4-quinoléinyl)oxy]phényl}-N'-(4-fluorophényl)-1,1-cyclopropanedicarboxamide (1:1) [French] [ACD/IUPAC Name]
Butanedioic acid, 2-hydroxy-, (2S)-, compd. with N-[4-[(6,7-dimethoxy-4- quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1)
Butanedioic acid, 2-hydroxy-, (2S)-, compd. with N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1) [ACD/Index Name]
cabozantinib L-malate
Cabozantinib L-Malate Salt
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

XL184 [DBID]
CCRIS 4693 [DBID]
PubChem Substance ID 329825761 [DBID]
XL-184 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Chemical Class:

      A malate salt that is the mono-(<stereo>S</stereo>)-malate salt of cabozantinib. A multi-tyrosine kinase inhibitor, used for the treatment of progressive, metastatic, medullary thyroid cancer. ChEBI CHEBI:72319
      A malate salt that is the mono-(S)-malate salt of cabozantinib. A multi-tyrosine kinase inhibitor, used for the treatment of progressive, metastatic, medullary thyroid cancer. ChEBI CHEBI:72319

    • Bio Activity:

      Cabozantinib S-malate (XL184, BMS-907351) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively.; IC50 value: 0.035 nM [1]; Target: VEGFR2; in vitro: XL184 has weak inhibitory activity against RON and PDGFR? with IC50 of 124 nM and 234 nM, respectivey, and has low activity against FGFR1 with IC50 of 5.294 ?M [1]. MedChem Express HY-12044
      Protein Tyrosine Kinase/RTK MedChem Express HY-12044
      Protein Tyrosine Kinase/RTK; MedChem Express HY-12044
      VEGFR MedChem Express HY-12044

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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