ChemSpider 2D Image | ML324 | C21H23N3O2

ML324

  • Molecular FormulaC21H23N3O2
  • Average mass349.426 Da
  • Monoisotopic mass349.179016 Da
  • ChemSpider ID26371988

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1222800-79-4 [RN]
Benzamide, N-[3-(dimethylamino)propyl]-4-(8-hydroxy-6-quinolinyl)- [ACD/Index Name]
MFCD28053518
ML324
ML-324
N-(3-(Dimethylamino)propyl)-4-(8-hydroxyquinolin-6-yl)benzamide
N-[3-(Dimethylamino)propyl]-4-(8-hydroxy-6-chinolinyl)benzamid [German] [ACD/IUPAC Name]
N-[3-(Diméthylamino)propyl]-4-(8-hydroxy-6-quinoléinyl)benzamide [French] [ACD/IUPAC Name]
N-[3-(Dimethylamino)propyl]-4-(8-hydroxy-6-quinolinyl)benzamide [ACD/IUPAC Name]
N-[3-(dimethylamino)propyl]-4-(8-hydroxyquinolin-6-yl)benzamide
More...
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      Cell Cycle/DNA Damage MedChem Express HY-12725
      Cell Cycle/DNA Damage; MedChem Express HY-12725
      Histone Demethylase MedChem Express HY-12725
      ML324 is a potent JMJD2 demethylase inhibitor with demonstrated antiviral activity. MedChem Express
      ML324 is a potent JMJD2 demethylase inhibitor with demonstrated antiviral activity.; IC50 value: 920 nM(JMJD2E) [1]; Target: JMJD2 demethylase inhibitor; ML324 is a probe molecule that displays submicromolar inhibitory activity toward JMJD2E (in vitro) and possesses excellent in vitro ADME properties. MedChem Express HY-12725
      ML324 is a potent JMJD2 demethylase inhibitor with demonstrated antiviral activity.;IC50 value: 920 nM(JMJD2E) [1];Target: JMJD2 demethylase inhibitorML324 is a probe molecule that displays submicromolar inhibitory activity toward JMJD2E (in vitro) and possesses excellent in vitro ADME properties. In contrast to previously reported inhibitors of the JMJD proteins, ML324 displays excellent cell permeability providing an opportunity for more extensive cell-based studies of JMJD2 enzymes to be undertaken. In addition, ML324 demonstrates potent anti-viral activity against both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection via inhibition viral IE gene expression. ML324 suppresses the formation of HSV plaques, even at high MOI, and blocks HSV-1 reactivation in a mouse ganglia explant model of latently infected mice. MedChem Express HY-12725

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.2±0.1 g/cm3
Boiling Point: 590.1±50.0 °C at 760 mmHg
Vapour Pressure: 0.0±1.7 mmHg at 25°C
Enthalpy of Vaporization: 91.3±3.0 kJ/mol
Flash Point: 310.7±30.1 °C
Index of Refraction: 1.629
Molar Refractivity: 104.5±0.3 cm3
#H bond acceptors: 5
#H bond donors: 2
#Freely Rotating Bonds: 6
#Rule of 5 Violations: 0
ACD/LogP: 2.22
ACD/LogD (pH 5.5): -0.79
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 1.00
ACD/LogD (pH 7.4): -0.07
ACD/BCF (pH 7.4): 1.00
ACD/KOC (pH 7.4): 1.25
Polar Surface Area: 65 Å2
Polarizability: 41.4±0.5 10-24cm3
Surface Tension: 52.5±3.0 dyne/cm
Molar Volume: 294.1±3.0 cm3

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