ChemSpider 2D Image | RAD140 | C20H16ClN5O2

RAD140

  • Molecular FormulaC20H16ClN5O2
  • Average mass393.826 Da
  • Monoisotopic mass393.099243 Da
  • ChemSpider ID26387625

  • defined stereocentres - 2 of 2 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1182367-47-0 [RN]
2-Chlor-4-({(1R,2S)-1-[5-(4-cyanphenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl}amino)-3-methylbenzonitril [German] [ACD/IUPAC Name]
2-Chloro-4-({(1R,2S)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl}amino)-3-methylbenzonitrile [ACD/IUPAC Name]
2-Chloro-4-({(1R,2S)-1-[5-(4-cyanophényl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl}amino)-3-méthylbenzonitrile [French] [ACD/IUPAC Name]
2-Chloro-4-[[(1R,2S)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]amino]-3-methylbenzonitrile
Benzonitrile, 2-chloro-4-[[(1R,2S)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]amino]-3-methyl- [ACD/Index Name]
RAD140
RAD-140
2-?chloro-?4-?[[(1R,?2S)?-?1-?[5-?(4-?cyanophenyl)?-?1,?3,?4-?oxadiazol-?2-?yl]?-?2-?hydroxypropyl]?amino]?-?3-?methyl-Benzonitrile
2-chloro-4-(((1R,2S)-1-(5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl)-2-hydroxypropyl)amino)-3-methylbenzonitrile
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  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      Androgen Receptor MedChem Express HY-14383
      RAD140 is a potent, orally bioavailable, nonsteroidal selective androgen receptor modulator (SARM). MedChem Express http://www.medchemexpress.com/emodin.html
      RAD140 is a potent, orally bioavailable, nonsteroidal selective androgen receptor modulator (SARM). ;IC50 value: 7 nM (Ki, fot androgen receptor) [1];Target: androgen receptor ;In vitro: RAD140 demonstrates excellent affinity for the androgen receptor (Ki = 7 nM) as well as good selectivity over other steroid hormone nuclear receptors, with the closest off target receptor being the progesterone receptor (IC50 = 750 nM). [1] RAD140 is a novel SARM with high affinity and specificity for AR, is orally available, and exhibits potent anabolic effects in rodents and nonhuman primates.[2];In vivo: The stability of RAD140 is high (t1/2 > 2 h) in incubations with rat, monkey, and human microsomes, and it also had good bioavailability in rats and monkeys. [1] RAD140 is also neuroprotective using the rat kainate lesion model. RAD140 is shown to exhibit peripheral tissue-specific androgen action that largely spared prostate, neural efficacy by activation of androgenic gene regulation effects, MedChem Express HY-14383

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.4±0.1 g/cm3
Boiling Point: 687.7±65.0 °C at 760 mmHg
Vapour Pressure: 0.0±2.3 mmHg at 25°C
Enthalpy of Vaporization: 105.9±3.0 kJ/mol
Flash Point: 369.7±34.3 °C
Index of Refraction: 1.652
Molar Refractivity: 101.9±0.4 cm3
#H bond acceptors: 7
#H bond donors: 2
#Freely Rotating Bonds: 7
#Rule of 5 Violations: 0
ACD/LogP: 3.02
ACD/LogD (pH 5.5): 2.93
ACD/BCF (pH 5.5): 98.69
ACD/KOC (pH 5.5): 931.32
ACD/LogD (pH 7.4): 2.93
ACD/BCF (pH 7.4): 98.69
ACD/KOC (pH 7.4): 931.32
Polar Surface Area: 119 Å2
Polarizability: 40.4±0.5 10-24cm3
Surface Tension: 78.2±5.0 dyne/cm
Molar Volume: 278.4±5.0 cm3

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