ChemSpider 2D Image | Truseltiq | C26H34Cl2N7O7P

Truseltiq

  • Molecular FormulaC26H34Cl2N7O7P
  • Average mass658.471 Da
  • Monoisotopic mass657.163452 Da
  • ChemSpider ID26615481

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1-(2,6-dichloro-3,5-dimethoxyphenyl)-3-(6-{[4-(4-ethylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)-3-methylurea; phosphoric acid
1310746-10-1 [RN]
INFIGRATINIB PHOSPHATE
Truseltiq
1310746-10-1 (phosphate)
3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-((4-(4-ethylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)-1-methylurea phosphate
3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-(4-(4-ethylpiperazin-1-yl)phenylamino)pyrimidin-4-yl)-1-methylurea phosphate
3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-(6-{[4-(4-ethyl-1-piperazinyl)phenyl]amino}-4-pyrimidinyl)-1-methylurea phosphate (1:1) [ACD/IUPAC Name]
Acide phosphorique - 3-(2,6-dichloro-3,5-diméthoxyphényl)-1-(6-{[4-(4-éthyl-1-pipérazinyl)phényl]amino}-4-pyrimidinyl)-1-méthylurée (1:1) [French] [ACD/IUPAC Name]
allyl 2-methyl-4-oxopiperidine-1-carboxylate
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

58BH47BV6S [DBID]
PubChem Substance ID 329825761 [DBID]
UNII:58BH47BV6S [DBID]
UNII-58BH47BV6S [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Therapeutical Effect:

      To treat cholangiocarcinoma whose disease meets certain criteria FDA Truseltiq

    • Bio Activity:

      FGFR MedChem Express HY-13311A
      NVP-BGJ398 phosphate (BGJ-398) is a novel selective, pan-specific FGFR inhibitor with IC50 of 0.9, 1.4, and 1 nM for FGFR1, FGFR2, and FGFR3, respectively; MedChem Express http://www.medchemexpress.com/NVP-BGJ398.html
      NVP-BGJ398 phosphate (BGJ-398) is a novel selective, pan-specific FGFR inhibitor with IC50 of 0.9, 1.4, and 1 nM for FGFR1, FGFR2, and FGFR3, respectively; >40-fold selective for FGFR versus FGFR4 and VEGFR2, and little activity to Abl, Fyn, Kit, Lck, Lyn and Yes.; IC50 Value: 0.9 nM (FGFR1); 1.4 nM (FGFR2); 1 nM (FGFR2) [1]; Target: FGFR1/2/3; in vitro: NVP-BGJ398 is a novel and selective fibroblast growth factor receptor (FGFR) inhibitor. MedChem Express HY-13311A
      NVP-BGJ398 phosphate (BGJ-398) is a novel selective, pan-specific FGFR inhibitor with IC50 of 0.9, 1.4, and 1 nM for FGFR1, FGFR2, and FGFR3, respectively; >40-fold selective for FGFR versus FGFR4 and VEGFR2, and little activity to Abl, Fyn, Kit, Lck, Lyn and Yes.;IC50 Value: 0.9 nM (FGFR1); 1.4 nM (FGFR2); 1 nM (FGFR2) [1];Target: FGFR1/2/3;In vitro: NVP-BGJ398 is a novel and selective fibroblast growth factor receptor (FGFR) inhibitor. NVP-BGJ398 inhibit FGFR1, FGFR2, FGFR3 with IC50 of 0.9 nM, 1.4 nM and 1 nM. NVP-BGJ398 inhibited FGFR1, FGFR2, and FGFR3 with single digit nmol/L IC50 in biochemical and cellular autophosphorylation assays and FGFR4 with 38- to 60-fold lower potency. NVP-BGJ398 significantly inhibits proliferation of cancer cell lines bearing FGF/FGFR genetic alterations across various cancer types.Among the 35 cell lines selected from the high-throughput assays, 28 were confirmed as sensitive to NVP-BGJ398 with IC50s ranging from 0.001 to 500 nM. Cancer cell line MedChem Express HY-13311A
      Protein Tyrosine Kinase/RTK MedChem Express HY-13311A
      Protein Tyrosine Kinase/RTK; MedChem Express HY-13311A

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


Advertisement