ChemSpider 2D Image | CEP-33779 | C24H26N6O2S

CEP-33779

  • Molecular FormulaC24H26N6O2S
  • Average mass462.567 Da
  • Monoisotopic mass462.183807 Da
  • ChemSpider ID28424124

More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

[1,2,4]Triazolo[1,5-a]pyridin-2-amine, N-[3-(4-methyl-1-piperazinyl)phenyl]-8-[4-(methylsulfonyl)phenyl]- [ACD/Index Name]
1257704-57-6 [RN]
CEP-33779
N-[3-(4-Methyl-1-piperazinyl)phenyl]-8-[4-(methylsulfonyl)phenyl][1,2,4]triazolo[1,5-a]pyridin-2-amin [German] [ACD/IUPAC Name]
N-[3-(4-Methyl-1-piperazinyl)phenyl]-8-[4-(methylsulfonyl)phenyl][1,2,4]triazolo[1,5-a]pyridin-2-amine [ACD/IUPAC Name]
N-[3-(4-Méthyl-1-pipérazinyl)phényl]-8-[4-(méthylsulfonyl)phényl][1,2,4]triazolo[1,5-a]pyridin-2-amine [French] [ACD/IUPAC Name]
[1,2,4]Triazolo[1,5-a]pyridin-2-amine,N-[3-(4-methyl-1-piperazinyl)phenyl]-8-[4-(methylsulfonyl)phenyl]-
[1257704-57-6]
1346168-57-7 [RN]
5-Deoxy-L-ribose [ACD/IUPAC Name]
More...
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Bio Activity:

      CEP-33779 is a novel, selective, and orally bioavailable inhibitor of JAK2 with IC50 of 1.8 nM. MedChem Express
      CEP-33779 is a novel, selective, and orally bioavailable inhibitor of JAK2 with IC50 of 1.8 nM.; IC50 value: 1.8 nM [1]; Target: JAK2 inhibitor; in vitro: CEP-33779 is a novel, orally active, selective JAK2 inhibitor, CEP-33779, induced regression of established colorectal tumors, reduced angiogenesis, and reduced proliferation of tumor cells [2]. MedChem Express HY-15343
      JAK MedChem Express HY-15343
      JAK/STAT Signaling MedChem Express HY-15343
      JAK/STAT Signaling; MedChem Express HY-15343

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.4±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.693
Molar Refractivity: 130.8±0.5 cm3
#H bond acceptors: 8
#H bond donors: 1
#Freely Rotating Bonds: 5
#Rule of 5 Violations: 0
ACD/LogP: 2.02
ACD/LogD (pH 5.5): 0.33
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 4.48
ACD/LogD (pH 7.4): 1.96
ACD/BCF (pH 7.4): 14.81
ACD/KOC (pH 7.4): 189.26
Polar Surface Area: 91 Å2
Polarizability: 51.9±0.5 10-24cm3
Surface Tension: 56.4±7.0 dyne/cm
Molar Volume: 341.1±7.0 cm3

Click to predict properties on the Chemicalize site






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