ChemSpider 2D Image | Eltrombopag olamine | C29H36N6O6

Eltrombopag olamine

  • Molecular FormulaC29H36N6O6
  • Average mass564.633 Da
  • Monoisotopic mass564.269653 Da
  • ChemSpider ID28475107

  • Double-bond stereo - Double-bond stereo

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

[1,1'-Biphenyl]-3-carboxylic acid, 3'-[(2Z)-2-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2'-hydroxy-, compd. with 2-aminoethanol (1:2) [ACD/Index Name]
3'-{(2Z)-2-[1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-yliden]hydrazino}-2'-hydroxy-3-biphenylcarbonsäure --2-aminoethanol (1:2) [German] [ACD/IUPAC Name]
3'-{(2Z)-2-[1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene]hydrazino}-2'-hydroxy-3-biphenylcarboxylic acid - 2-aminoethanol (1:2) [ACD/IUPAC Name]
496775-62-3 [RN]
4U07F515LG
Acide 3'-{(2Z)-2-[1-(3,4-diméthylphényl)-3-méthyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidène]hydrazino}-2'-hydroxy-3-biphénylcarboxylique - 2-aminoéthanol (1:2) [French] [ACD/IUPAC Name]
Eltrombopag olamine [USAN]
Promacta [Trade name]
Revolade [Trade name]
UNII-4U07F515LG
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

SB-497115-GR [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      Eltrombopag olamine is a new, orally active thrombopoietin-receptor (c-mpl) agonist that stimulates thrombopoiesis. MedChem Express
      Eltrombopag olamine is a new, orally active thrombopoietin-receptor (c-mpl) agonist that stimulates thrombopoiesis.; IC50 Value: 0.27 uM (EC50 in murine BAF3 cells) [1]; Target: thrombopoietin-receptor (c-mpl); Potential advantages of eltrombopag may include a sustained platelet response and a good tolerability profile.; in vitro: Eltrombopag demonstrated a half maximal effective concentration (EC50) of 0.27 uM in murine BAF3 cells transfected with the luciferase reporter gene under direction of the STAT-activated IRF-1 promoter and human TpoR (BAF3/IRF-1/hTpoR) [1]. MedChem Express HY-15306A
      Eltrombopag olamine is a new, orally active thrombopoietin-receptor (c-mpl) agonist that stimulates thrombopoiesis.;IC50 Value: 0.27 uM (EC50 in murine BAF3 cells) [1];Target: thrombopoietin-receptor (c-mpl)Potential advantages of eltrombopag may include a sustained platelet response and a good tolerability profile.;In vitro: Eltrombopag demonstrated a half maximal effective concentration (EC50) of 0.27 uM in murine BAF3 cells transfected with the luciferase reporter gene under direction of the STAT-activated IRF-1 promoter and human TpoR (BAF3/IRF-1/hTpoR) [1]. Eltrombopag stimulates the growth of TPO-dependent cell lines via JAK2 and STAT signaling pathways and stimulates isolated human CD34+ cells to become megakaryocytes and produce platelets [2].;In vivo: Twelve weeks of antiviral therapy, with concurrent receipt of eltrombopag or placebo, were completed by 36%, 53%, and 65% of patients receiving 30 mg, 50 mg, and 75 mg of eltrombopag, respectively, and by 6% of patients in MedChem Express HY-15306A
      Others MedChem Express HY-15306A
      Thrombopoietin Receptor MedChem Express HY-15306A

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

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