ChemSpider 2D Image | BIX 02565 | C26H30N6O2

BIX 02565

  • Molecular FormulaC26H30N6O2
  • Average mass458.555 Da
  • Monoisotopic mass458.243011 Da
  • ChemSpider ID28490994

  • defined stereocentres - 1 of 1 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(5R)-N-{1-[3-(dimethylamino)propyl]-1,3-benzodiazol-2-yl}-5-methyl-1-oxo-2H,3H,4H,5H-[1,4]diazepino[1,2-a]indole-8-carboxamide
(5R)-N-{1-[3-(dimethylamino)propyl]-1H-1,3-benzodiazol-2-yl}-5-methyl-1-oxo-1H,2H,3H,4H,5H-[1,4]diazepino[1,2-a]indole-8-carboxamide
(5R)-N-{1-[3-(Dimethylamino)propyl]-1H-benzimidazol-2-yl}-5-methyl-1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indol-8-carboxamid [German] [ACD/IUPAC Name]
(5R)-N-{1-[3-(Dimethylamino)propyl]-1H-benzimidazol-2-yl}-5-methyl-1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole-8-carboxamide [ACD/IUPAC Name]
(5R)-N-{1-[3-(Diméthylamino)propyl]-1H-benzimidazol-2-yl}-5-méthyl-1-oxo-2,3,4,5-tétrahydro-1H-[1,4]diazépino[1,2-a]indole-8-carboxamide [French] [ACD/IUPAC Name]
1311367-27-7 [RN]
1H-[1,4]Diazepino[1,2-a]indole-8-carboxamide, N-[1-[3-(dimethylamino)propyl]-1H-benzimidazol-2-yl]-2,3,4,5-tetrahydro-5-methyl-1-oxo-, (5R)- [ACD/Index Name]
BIX 02565
(5R)?-N-?[1-?[3-?(dimethylamino)?propyl]?-?1H-?benzimidazol-?2-?yl]?-?2,?3,?4,?5-?tetrahydro-?5-?methyl-?1-?oxo-1H-?[1,?4]?Diazepino[1,?2-?a]?indole-?8-?carboxamide?
(5R)-N-[1-[3-(dimethylamino)propyl]-1H-benzimidazol-2-yl]-2,3,4,5-tetrahydro-5-methyl-1-oxo-1H-[1,4]diazepino[1,2-a]indole-8-carboxamide
More...
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      BIX 02565 is a novel ribosomal S6 kinase 2 (RSK2) inhibitor with an IC50 of 1.1 nM. MedChem Express
      BIX 02565 is a novel ribosomal S6 kinase 2 (RSK2) inhibitor with an IC50 of 1.1 nM.; IC50 Value: 1.1 nM (RSK2) [1]; Target: RSK2; BIX 02565 is an attractive candidate for use in vitro and in vivo to explore the role of RSK as a target for the treatment heart failure. MedChem Express HY-16104
      MAPK MedChem Express HY-16104
      MAPK; MedChem Express HY-16104
      Ribosomal S6 Kinase (RSK) MedChem Express HY-16104

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.3±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.686
Molar Refractivity: 131.8±0.5 cm3
#H bond acceptors: 8
#H bond donors: 2
#Freely Rotating Bonds: 6
#Rule of 5 Violations: 0
ACD/LogP: 2.67
ACD/LogD (pH 5.5): -0.44
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 1.00
ACD/LogD (pH 7.4): 0.52
ACD/BCF (pH 7.4): 1.00
ACD/KOC (pH 7.4): 4.96
Polar Surface Area: 84 Å2
Polarizability: 52.3±0.5 10-24cm3
Surface Tension: 52.9±7.0 dyne/cm
Molar Volume: 346.6±7.0 cm3

Click to predict properties on the Chemicalize site


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