ChemSpider 2D Image | Vortioxetine hydrobromide | C18H23BrN2S

Vortioxetine hydrobromide

  • Molecular FormulaC18H23BrN2S
  • Average mass379.358 Da
  • Monoisotopic mass378.076538 Da
  • ChemSpider ID28528540

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

Vortioxetine hydrobromide [USAN]
1-(2-((2,4-Dimethylphenyl)sulfanyl)phenyl)piperazine monohydrobromide
1-{2-[(2,4-dimethylphenyl)sulfanyl]phenyl}piperazine hydrobromide
1-{2-[(2,4-Dimethylphenyl)sulfanyl]phenyl}piperazine hydrobromide (1:1) [ACD/IUPAC Name]
1-{2-[(2,4-Diméthylphényl)sulfanyl]phényl}pipérazine, bromhydrate (1:1) [French] [ACD/IUPAC Name]
1-{2-[(2,4-Dimethylphenyl)sulfanyl]phenyl}piperazinhydrobromid (1:1) [German] [ACD/IUPAC Name]
960203-27-4 [RN]
Brintellix [Trade name]
Piperazine, 1-[2-[(2,4-dimethylphenyl)thio]phenyl]-, hydrobromide (1:1) [ACD/Index Name]
VORTIOXETINE HBr
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

Lu AA21004 (HBr) [DBID]
TKS641KOAY [DBID]
UNII:TKS641KOAY [DBID]
UNII-TKS641KOAY [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      5-HT Receptor modulator TargetMol T2395L

    • Chemical Class:

      A hydrobromide obtained by combining vortioxetine with one molar equivalent of hydrobromic acid. Used for treatment of major depressive disorder. ChEBI https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:76015, CHEBI:76015

    • Bio Activity:

      5-HT Receptor MedChem Express HY-15414A
      5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor, SERT TargetMol T2395L
      GPCR/G protein MedChem Express HY-15414A
      GPCR/G protein; Neuronal Signaling; MedChem Express HY-15414A
      Neuroscience TargetMol T2395L
      Vortioxetine Hcl (Lu AA21004 Hcl) is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with IC50 of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.; IC50 Value: 15nM (5-HT1A); 33nM (5-HT1B); 3.7nM(5-HT3A); 19nM (5-HT7); 1.6 nM(SERT) [1]; Target: 5-HT receptor; in vitro: Compound 5m (Lu AA21004) was the lead compound, displaying high affinity for recombinant human 5-HT(1A) (K(i) = 15 nM), 5-HT(1B) (K(i) = 33 nM), 5-HT(3A) (K(i) = 3.7 nM), 5-HT(7) (K(i) = 19 nM), and noradrenergic ?(1) (K(i) = 46 nM) receptors, and SERT (K(i) = 1.6 nM). MedChem Express HY-15414A

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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