ChemSpider 2D Image | Icotinib hydrochloride | C22H22ClN3O4

Icotinib hydrochloride

  • Molecular FormulaC22H22ClN3O4
  • Average mass427.881 Da
  • Monoisotopic mass427.129883 Da
  • ChemSpider ID28637803

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

[1,4,7,10]Tetraoxacyclododecino[2,3-g]quinazolin-4-amine, N-(3-ethynylphenyl)-7,8,10,11,13,14-hexahydro-, hydrochloride (1:1) [ACD/Index Name]
1204313-51-8 [RN]
Icotinib hydrochloride
N-(3-Ethinylphenyl)-7,8,10,11,13,14-hexahydro[1,4,7,10]tetraoxacyclododecino[2,3-g]chinazolin-4-aminhydrochlorid (1:1) [German] [ACD/IUPAC Name]
N-(3-Ethynylphenyl)-7,8,10,11,13,14-hexahydro[1,4,7,10]tetraoxacyclododecino[2,3-g]quinazolin-4-amine hydrochloride (1:1) [ACD/IUPAC Name]
N-(3-Éthynylphényl)-7,8,10,11,13,14-hexahydro[1,4,7,10]tétraoxacyclododécino[2,3-g]quinazolin-4-amine, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
[1204313-51-8] [RN]
1204313-51-8 (HCl)
BPI-2009H
Icotinib
More...
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      EGFR inhibitor TargetMol T2307

    • Bio Activity:

      EGFR MedChem Express HY-15164
      EGFR and EGFR mutants TargetMol T2307
      Icotinib Hcl(BPI-2009H) is a potent and specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) with an IC(50) of 5 nM, including it's mutants of EGFR(L858R), EGFR(L861Q), EGF R(T790M) and EGFR(T790M, L858R). MedChem Express
      Icotinib Hcl(BPI-2009H) is a potent and specific epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) with an IC(50) of 5 nM, including it's mutants of EGFR(L858R), EGFR(L861Q), EGFR(T790M) and EGFR(T790M, L858R).;IC50 value: 5 nM;Target: EGFR and EGFR mutants;In vitro: Icotinib inhibits EGFR activity in a dose-dependent manner, with an IC50 value of 5 nM and complete inhibition at 62.5 nM. Icotinib selectively solely inhibits the EGFR members including the wild type and mutants with inhibition efficacies of 61-99%. Icotinib blocks EGFR-mediated intracellular tyrosine phosphorylation in human epidermoid carcinoma A431 cells in a dose-dependent manner. Meanwhile, in our proliferation assay performed on A431, BGC-823, A549, H460, HCT8, KB and Bel-7402 cell lines, we found that the relative sensitivity of cell lines to Icotinib is A431 > BGC-823 > A549 > H460 > KB > HCT8 and Bel-7402. Icotinib exhibits a broad spectrum of antitumor activity and it is especially effe MedChem Express HY-15164
      JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; MedChem Express HY-15164
      Tyrosine Kinase/Adaptors TargetMol T2307

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

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