ChemSpider 2D Image | BMS-911543 | C23H28N8O

BMS-911543

  • Molecular FormulaC23H28N8O
  • Average mass432.521 Da
  • Monoisotopic mass432.238617 Da
  • ChemSpider ID29315033

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1271022-90-2 [RN]
BMS-911543
Imidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide, N,N-dicyclopropyl-4-[(1,5-dimethyl-1H-pyrazol-3-yl)amino]-6-ethyl-1,6-dihydro-1-methyl- [ACD/Index Name]
N,N-Dicyclopropyl-4-[(1,5-dimethyl-1H-pyrazol-3-yl)amino]-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-carboxamid [German] [ACD/IUPAC Name]
N,N-Dicyclopropyl-4-[(1,5-dimethyl-1H-pyrazol-3-yl)amino]-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide [ACD/IUPAC Name]
N,N-Dicyclopropyl-4-[(1,5-diméthyl-1H-pyrazol-3-yl)amino]-6-éthyl-1-méthyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide [French] [ACD/IUPAC Name]
N,N-dicyclopropyl-7-[(1,5-dimethyl-1H-pyrazol-3-yl)amino]-10-ethyl-3-methyl-3,5,8,10-tetraazatricyclo[7.3.0.0²,?]dodeca-1,4,6,8,11-pentaene-11-carboxamide
[1271022-90-2] [RN]
3-Azabicyclo[3.2.1]octan-2-one [ACD/Index Name] [ACD/IUPAC Name]
50V
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

7N03P021J8 [DBID]
UNII:7N03P021J8 [DBID]
UNII-7N03P021J8 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      BMS-911543 is a potent and selective small-molecule inhibitor of JAK2, displays potent anti-proliferative and pharmacodynamic (PD) effects in cell lines dependent upon JAK2 signaling.; IC50 value:; Target: JAK2; BMS-911543 displays potent anti-proliferative and pharmacodynamic (PD) effects in cell lines dependent upon JAK2 signaling, and has little activity in cell types dependent upon other pathways, such as JAK1 and JAK3. MedChem Express HY-15270
      BMS-911543 is a potent and selective small-molecule inhibitor of JAK2, displays potent anti-proliferative and pharmacodynamic (PD) effects in cell lines dependent upon JAK2 signaling.;IC50 value:;Target: JAK2BMS-911543 displays potent anti-proliferative and pharmacodynamic (PD) effects in cell lines dependent upon JAK2 signaling, and has little activity in cell types dependent upon other pathways, such as JAK1 and JAK3. BMS-911543 also displays anti-proliferative responses in colony growth assays using primary progenitor cells isolated from patients with JAK2(V617F)-positive myeloproliferative neoplasms (MPNs). Similar to these in vitro observations, BMS-911543 is also highly active in in vivo models of JAK2 signaling, with sustained pathway suppression being observed after a single oral dose. MedChem Express HY-15270
      BMS-911543 is a potent and selective small-molecule inhibitor of JAK2; displayes potent anti-proliferative and pharmacodynamic (PD) effects in cell lines dependent upon JAK2 signaling. MedChem Express
      JAK MedChem Express HY-15270
      JAK/STAT Signaling MedChem Express HY-15270
      JAK/STAT Signaling; MedChem Express HY-15270

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.5±0.1 g/cm3
Boiling Point: 709.5±70.0 °C at 760 mmHg
Vapour Pressure: 0.0±2.3 mmHg at 25°C
Enthalpy of Vaporization: 103.8±3.0 kJ/mol
Flash Point: 382.9±35.7 °C
Index of Refraction: 1.788
Molar Refractivity: 121.4±0.5 cm3
#H bond acceptors: 9
#H bond donors: 1
#Freely Rotating Bonds: 6
#Rule of 5 Violations: 0
ACD/LogP: 1.42
ACD/LogD (pH 5.5): 2.20
ACD/BCF (pH 5.5): 26.36
ACD/KOC (pH 5.5): 338.15
ACD/LogD (pH 7.4): 2.31
ACD/BCF (pH 7.4): 33.38
ACD/KOC (pH 7.4): 428.27
Polar Surface Area: 86 Å2
Polarizability: 48.1±0.5 10-24cm3
Surface Tension: 61.6±7.0 dyne/cm
Molar Volume: 287.2±7.0 cm3

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