ChemSpider 2D Image | Ribociclib hydrochloride | C23H31ClN8O

Ribociclib hydrochloride

  • Molecular FormulaC23H31ClN8O
  • Average mass470.998 Da
  • Monoisotopic mass470.230927 Da
  • ChemSpider ID32702923

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1211443-80-9 [RN]
7-Cyclopentyl-N,N-dimethyl-2-{[5-(1-piperazinyl)-2-pyridinyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-6-carboxamidhydrochlorid (1:1) [German] [ACD/IUPAC Name]
7-Cyclopentyl-N,N-dimethyl-2-{[5-(1-piperazinyl)-2-pyridinyl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide hydrochloride (1:1) [ACD/IUPAC Name]
7-Cyclopentyl-N,N-diméthyl-2-{[5-(1-pipérazinyl)-2-pyridinyl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide hydrochloride
7H-Pyrrolo[2,3-d]pyrimidine-6-carboxamide, 7-cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-, hydrochloride (1:1) [ACD/Index Name]
Ribociclib hydrochloride
1211441-98-3 [RN]
1211443-80-9 (HCl)
7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid dimethylamide hydrochloride
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

63YF7YKW7E [DBID]
UNII:63YF7YKW7E [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      CDK MedChem Express HY-15777A
      Cell Cycle/DNA Damage MedChem Express HY-15777A
      Cell Cycle/DNA Damage; MedChem Express HY-15777A
      LEE011 Hcl is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. MedChem Express http://www.medchemexpress.com/whi-p180-hydrochloride.html, HY-15777A
      LEE011 Hcl is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. ;IC50 Value: 307 ? 68 nM (neuroblastoma-derived cell lines) [1];Target: CDK4;CDK6;In vitro: CDK4/6 inhibitor LEE011 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation.Treatment with LEE011 significantly reduced proliferation in 12 of 17 human neuroblastoma-derived cell lines by inducing cytostasis at nanomolar concentrations (mean IC50 = 307 ? 68 nmol/L in sensitive lines). LEE011 caused cell-cycle arrest and cellular senescence that was attributed to dose-dependent decreases in phosp MedChem Express HY-15777A

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


Advertisement