ChemSpider 2D Image | AZD 8186 | C24H25F2N3O4

AZD 8186

  • Molecular FormulaC24H25F2N3O4
  • Average mass457.470 Da
  • Monoisotopic mass457.181305 Da
  • ChemSpider ID35000182

  • defined stereocentres - 1 of 1 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1627494-13-6 [RN]
4H-1-Benzopyran-6-carboxamide, 8-[(1R)-1-[(3,5-difluorophenyl)amino]ethyl]-N,N-dimethyl-2-(4-morpholinyl)-4-oxo- [ACD/Index Name]
8-[(1R)-1-[(3,5-difluorophenyl)amino]ethyl]-N,N-dimethyl-2-(morpholin-4-yl)-4-oxo-4H-chromene-6-carboxamide
8-[(1R)-1-[(3,5-difluorophenyl)amino]ethyl]-N,N-dimethyl-2-(morpholin-4-yl)-4-oxochromene-6-carboxamide
8-{(1R)-1-[(3,5-Difluorophenyl)amino]ethyl}-N,N-dimethyl-2-(4-morpholinyl)-4-oxo-4H-chromene-6-carboxamide [ACD/IUPAC Name]
8-{(1R)-1-[(3,5-Difluorophényl)amino]éthyl}-N,N-diméthyl-2-(4-morpholinyl)-4-oxo-4H-chromène-6-carboxamide [French] [ACD/IUPAC Name]
8-{(1R)-1-[(3,5-Difluorphenyl)amino]ethyl}-N,N-dimethyl-2-(4-morpholinyl)-4-oxo-4H-chromen-6-carboxamid [German] [ACD/IUPAC Name]
AIQ4OWD0RA
AZD 8186
AZD-8186
More...
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      AZD8186 is an isoform-specific small-molecule PI3K inhibitor, potently inhibits PI3K? (IC50=4 nM) and PI3K? (IC50=12 nM) with selectivity over PI3K? (IC50=35 nM) and PI3K? (IC50=675 nM).; IC50 value: 4 nM (PI3K?), 12 nM (PI3K?); Target: PI3K; in vitro: AZD8186 selectively inhibits PI3K?- and ?-mediated signaling through AKT. MedChem Express HY-12330
      PI3K MedChem Express HY-12330
      PI3K/Akt/mTOR MedChem Express HY-12330
      PI3K/Akt/mTOR; MedChem Express HY-12330

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.4±0.1 g/cm3
Boiling Point: 645.2±55.0 °C at 760 mmHg
Vapour Pressure: 0.0±1.9 mmHg at 25°C
Enthalpy of Vaporization: 95.2±3.0 kJ/mol
Flash Point: 344.0±31.5 °C
Index of Refraction: 1.618
Molar Refractivity: 118.5±0.3 cm3
#H bond acceptors: 7
#H bond donors: 1
#Freely Rotating Bonds: 5
#Rule of 5 Violations: 0
ACD/LogP: 2.79
ACD/LogD (pH 5.5): 2.73
ACD/BCF (pH 5.5): 69.43
ACD/KOC (pH 5.5): 723.80
ACD/LogD (pH 7.4): 2.73
ACD/BCF (pH 7.4): 69.51
ACD/KOC (pH 7.4): 724.71
Polar Surface Area: 71 Å2
Polarizability: 47.0±0.5 10-24cm3
Surface Tension: 55.2±3.0 dyne/cm
Molar Volume: 338.4±3.0 cm3

Click to predict properties on the Chemicalize site


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