ChemSpider 2D Image | EPZ020411 | C25H38N4O3

EPZ020411

  • Molecular FormulaC25H38N4O3
  • Average mass442.594 Da
  • Monoisotopic mass442.294403 Da
  • ChemSpider ID35035394

  • defined stereocentres - 2 of 2 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1,2-Ethanediamine, N1,N2-dimethyl-N1-[[3-[4-[[trans-3-[2-(tetrahydro-2H-pyran-4-yl)ethoxy]cyclobutyl]oxy]phenyl]-1H-pyrazol-4-yl]methyl]- [ACD/Index Name]
1700663-41-7 [RN]
EPZ020411
N,N'-Dimethyl-N-({3-[4-({trans-3-[2-(tetrahydro-2H-pyran-4-yl)ethoxy]cyclobutyl}oxy)phenyl]-1H-pyrazol-4-yl}methyl)-1,2-ethandiamin [German] [ACD/IUPAC Name]
N,N'-Dimethyl-N-({3-[4-({trans-3-[2-(tetrahydro-2H-pyran-4-yl)ethoxy]cyclobutyl}oxy)phenyl]-1H-pyrazol-4-yl}methyl)-1,2-ethanediamine [ACD/IUPAC Name]
N,N'-Diméthyl-N-({3-[4-({trans-3-[2-(tétrahydro-2H-pyran-4-yl)éthoxy]cyclobutyl}oxy)phényl]-1H-pyrazol-4-yl}méthyl)-1,2-éthanediamine [French] [ACD/IUPAC Name]
N,N'-Dimethyl-N-({3-[4-({trans-3-[2-(Tetrahydro-2h-Pyran-4-Yl)ethoxy]cyclobutyl}oxy)phenyl]-1h-Pyrazol-4-Yl}methyl)ethane-1,2-Diamine
1-1,5-Dihydro-pyrrol-2-one
1H-pyrrol-2(5H)-one
49L
More...
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      Cell Cycle/DNA Damage MedChem Express HY-12970
      Cell Cycle/DNA Damage; MedChem Express HY-12970
      EPZ020411 is a potent and selective inhibitor of PRMT6 with IC50 of 10 nM, has ?10 fold selectivity for PRMT6 over PRMT1 and PRMT8.; IC50 value: 10 nM; Target: PRMT6; in vitro: EPZ020411 inhibits methylation of PRMT6 substrates in cells. MedChem Express HY-12970
      HMTase MedChem Express HY-12970

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.2±0.1 g/cm3
Boiling Point: 619.2±55.0 °C at 760 mmHg
Vapour Pressure: 0.0±1.8 mmHg at 25°C
Enthalpy of Vaporization: 91.8±3.0 kJ/mol
Flash Point: 328.3±31.5 °C
Index of Refraction: 1.579
Molar Refractivity: 125.9±0.4 cm3
#H bond acceptors: 7
#H bond donors: 2
#Freely Rotating Bonds: 12
#Rule of 5 Violations: 0
ACD/LogP: 1.92
ACD/LogD (pH 5.5): -0.89
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 1.00
ACD/LogD (pH 7.4): 0.51
ACD/BCF (pH 7.4): 1.00
ACD/KOC (pH 7.4): 4.65
Polar Surface Area: 72 Å2
Polarizability: 49.9±0.5 10-24cm3
Surface Tension: 53.1±5.0 dyne/cm
Molar Volume: 378.7±5.0 cm3

Click to predict properties on the Chemicalize site


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