ChemSpider 2D Image | AM281 | C21H19Cl2IN4O2

AM281

  • Molecular FormulaC21H19Cl2IN4O2
  • Average mass557.212 Da
  • Monoisotopic mass555.992981 Da
  • ChemSpider ID3508737

More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(4-morpholinyl)-1H-pyrazole-3-carboxamide [ACD/IUPAC Name]
1-(2,4-Dichlorophényl)-5-(4-iodophényl)-4-méthyl-N-(4-morpholinyl)-1H-pyrazole-3-carboxamide [French] [ACD/IUPAC Name]
1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(morpholin-4-yl)-1H-pyrazole-3-carboxamide
1-(2,4-DICHLOROPHENYL)-5-(4-IODOPHENYL)-4-METHYL-N-(MORPHOLIN-4-YL)PYRAZOLE-3-CARBOXAMIDE
1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide
1-(2,4-Dichlorphenyl)-5-(4-iodphenyl)-4-methyl-N-(4-morpholinyl)-1H-pyrazol-3-carboxamid [German] [ACD/IUPAC Name]
1H-Pyrazole-3-carboxamide, 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl- [ACD/Index Name]
202463-68-1 [RN]
AM 281
AM281
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

A0980_SIGMA [DBID]
NCGC00025009-01 [DBID]
Tocris-1115 [DBID]
  • References
  • Experimental Physico-chemical Properties
    • Experimental Solubility:

      Soluble in DMSO (50 mM with heating) Hello Bio HB2312
      Soluble to 100 mM in DMSO Tocris Bioscience 1115
      Soluble to 75 mM in DMSO Tocris Bioscience 1115
      Soluble to 75 mM in DMSO with gentle warming Tocris Bioscience 1115
  • Miscellaneous
    • Safety:

      Sold with the permission of the University of Connecticut Tocris Bioscience 1115
    • Target Organs:

      Cannabinoid antagonist TargetMol T2264
    • Bio Activity:

      7-TM Receptors Tocris Bioscience 1115
      AM 281 is a potent, selective CB<sub>1</sub> receptor antagonist / inverse agonist which is selective for CB<sub>1</sub> over CB<sub>2</sub> receptors (K<sub>i</sub> values are 12 nM and 4200 nM respectively). AM 281 modulates locomotor activity and shows neuroprotective actions in septic shock. Hello Bio HB2312
      Biochemicals & small molecules/Antagonists & inhibitors Hello Bio HB2312
      Cannabinoid receptor TargetMol T2264
      Cannabinoid Receptors Tocris Bioscience 1115
      CB1 Receptors Tocris Bioscience 1115
      Neuroscience TargetMol T2264
      Potent, selective CB<sub>1</sub> receptor antagonist / inverse agonist Hello Bio HB2312
      Potent, selective CB1 antagonist/inverse agonist Tocris Bioscience 1115
      Potent, selective CB1 cannabinoid receptor antagonist/inverse agonist (Ki values are 12 and 4200 nM for CB1 and CB2 receptors respectively). Increases locomotor activity following systemic administrat ion in vivo. Analog of SR141716A (Ki = 14 nM). Tocris Bioscience 1115
      Potent, selective CB1 cannabinoid receptor antagonist/inverse agonist (Ki values are 12 and 4200 nM for CB1 and CB2 receptors respectively). Increases locomotor activity following systemic administration in vivo. Analog of SR141716A (Ki = 14 nM). Tocris Bioscience 1115
      Receptors & Transporters/G protein coupled receptors/Cannabinoid/CB<sub>1</sub> Hello Bio HB2312

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.7±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.706
Molar Refractivity: 127.1±0.5 cm3
#H bond acceptors: 6
#H bond donors: 1
#Freely Rotating Bonds: 4
#Rule of 5 Violations: 1
ACD/LogP: 4.90
ACD/LogD (pH 5.5): 4.63
ACD/BCF (pH 5.5): 1946.25
ACD/KOC (pH 5.5): 7870.53
ACD/LogD (pH 7.4): 4.63
ACD/BCF (pH 7.4): 1945.42
ACD/KOC (pH 7.4): 7867.20
Polar Surface Area: 59 Å2
Polarizability: 50.4±0.5 10-24cm3
Surface Tension: 55.6±7.0 dyne/cm
Molar Volume: 326.5±7.0 cm3

Click to predict properties on the Chemicalize site






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