ChemSpider 2D Image | AM281 | C21H19Cl2IN4O2

AM281

  • Molecular FormulaC21H19Cl2IN4O2
  • Average mass557.212 Da
  • Monoisotopic mass555.992981 Da
  • ChemSpider ID3508737

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(4-morpholinyl)-1H-pyrazole-3-carboxamide [ACD/IUPAC Name]
1-(2,4-Dichlorophényl)-5-(4-iodophényl)-4-méthyl-N-(4-morpholinyl)-1H-pyrazole-3-carboxamide [French] [ACD/IUPAC Name]
1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(morpholin-4-yl)-1H-pyrazole-3-carboxamide
1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-1H-pyrazole-3-carboxamide
1-(2,4-Dichlorphenyl)-5-(4-iodphenyl)-4-methyl-N-(4-morpholinyl)-1H-pyrazol-3-carboxamid [German] [ACD/IUPAC Name]
1H-Pyrazole-3-carboxamide, 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl- [ACD/Index Name]
202463-68-1 [RN]
AM 281
AM281
AM-281
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

A0980_SIGMA [DBID]
NCGC00025009-01 [DBID]
Tocris-1115 [DBID]
  • References
  • Experimental Physico-chemical Properties

    • Experimental Solubility:

      Soluble to 100 mM in DMSO Tocris Bioscience 1115
      Soluble to 75 mM in DMSO Tocris Bioscience 1115
      Soluble to 75 mM in DMSO with gentle warming Tocris Bioscience 1115
  • Miscellaneous

    • Safety:

      Sold with the permission of the University of Connecticut Tocris Bioscience 1115

    • Target Organs:

      Cannabinoid antagonist TargetMol T2264

    • Bio Activity:

      7-TM Receptors Tocris Bioscience 1115
      AM 281 is a potent, selective CB<sub>1</sub> receptor antagonist / inverse agonist which is selective for CB<sub>1</sub> over CB<sub>2</sub> receptors (K<sub>i</sub> values are 12 nM and 4200 nM respectively). AM 281 modulates locomotor activity and shows neuroprotective actions in septic shock. Hello Bio [HB2312]
      Biochemicals & small molecules/Antagonists & inhibitors Hello Bio [HB2312]
      Cannabinoid receptor TargetMol T2264
      Cannabinoid Receptors Tocris Bioscience 1115
      CB1 Receptors Tocris Bioscience 1115
      Neuroscience TargetMol T2264
      Potent, selective CB<sub>1</sub> receptor antagonist / inverse agonist Hello Bio [HB2312]
      Potent, selective CB1 antagonist/inverse agonist Tocris Bioscience 1115
      Potent, selective CB1 cannabinoid receptor antagonist/inverse agonist (Ki values are 12 and 4200 nM for CB1 and CB2 receptors respectively). Increases locomotor activity following systemic administrat ion in vivo. Analog of SR141716A (Ki = 14 nM). Tocris Bioscience 1115
      Potent, selective CB1 cannabinoid receptor antagonist/inverse agonist (Ki values are 12 and 4200 nM for CB1 and CB2 receptors respectively). Increases locomotor activity following systemic administration in vivo. Analog of SR141716A (Ki = 14 nM). Tocris Bioscience 1115
      Receptors & Transporters/G protein coupled receptors/Cannabinoid/CB<sub>1</sub> Hello Bio [HB2312]

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.7±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.706
Molar Refractivity: 127.1±0.5 cm3
#H bond acceptors: 6
#H bond donors: 1
#Freely Rotating Bonds: 4
#Rule of 5 Violations: 1
ACD/LogP: 4.90
ACD/LogD (pH 5.5): 4.63
ACD/BCF (pH 5.5): 1946.25
ACD/KOC (pH 5.5): 7870.53
ACD/LogD (pH 7.4): 4.63
ACD/BCF (pH 7.4): 1945.42
ACD/KOC (pH 7.4): 7867.20
Polar Surface Area: 59 Å2
Polarizability: 50.4±0.5 10-24cm3
Surface Tension: 55.6±7.0 dyne/cm
Molar Volume: 326.5±7.0 cm3

Click to predict properties on the Chemicalize site


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