ChemSpider 2D Image | Flecainide acetate | C19H24F6N2O5

Flecainide acetate

  • Molecular FormulaC19H24F6N2O5
  • Average mass474.395 Da
  • Monoisotopic mass474.158936 Da
  • ChemSpider ID37445

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

54143-56-5 [RN]
Acide acétique - N-(2-pipéridinylméthyl)-2,5-bis(2,2,2-trifluoroéthoxy)benzamide (1:1) [French] [ACD/IUPAC Name]
acide acétique - N-(pipéridin-2-ylméthyl)-2,5-bis(2,2,2-trifluoroéthoxy)benzamide (1:1)
Benzamide, N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)-, acetate (1:1) [ACD/Index Name]
Flecainide (acetate)
Flecainide acetate
Flecainide acetate salt
MFCD00214290 [MDL number]
N-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluorethoxy)benzamidacetat (1:1) [German] [ACD/IUPAC Name]
N-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide acetate (1:1) [ACD/IUPAC Name]
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

M8U465Q1WQ [DBID]
UNII:M8U465Q1WQ [DBID]
D00638 [DBID]
E-0735 [DBID]
EU-0100546 [DBID]
F6777_SIGMA [DBID]
MLS000069675 [DBID]
R 818 [DBID]
R-818 [DBID]
SMR000058451 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Chemical Class:

      An acetate salt obtained by combining flecainide with one molar equivalent of acetic acid. An antiarrhythmic agent used to prevent and treat tachyarrhythmia (abnormal fast rhythm of the heart). ChEBI https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:5091, CHEBI:5091

    • Bio Activity:

      Cardiac Na+ channel blocker. Antiarrhythmic Tocris Bioscience 1470
      Flecainide(Tambocor) is a class 1C antiarrhythmic drug especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential.; IC50 Value:; Target: Nav1.5 channel; Flecainide is a class 1C antiarrhythmic drug especially used for the management of supraventricular arrhythmia. MedChem Express HY-17429
      Flecainide(Tambocor) is a class 1C antiarrhythmic drug especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential.;IC50 Value:;Target: Nav1.5 channelFlecainide is a class 1C antiarrhythmic drug especially used for the management of supraventricular arrhythmia. Flecainide works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential.;In vitro: Under the current-clamp condition, flecainide (1-100 microM) prolonged the action potential duration at both the early and the late phases of repolarization in a concentration-dependent manner without affecting the resting membrane potential [1]. At a holding potential (HP) of -120 mV, flecainide use-dependently blocked WT and G1306E I(Na) equally but was more potent on R1448C channels. For WT, the extent of block depended on a holding voltage more negative than the activation MedChem Express HY-17429
      Flecainide(Tambocor) is a class 1C antiarrhythmic drug especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential. MedChem Express
      Ion Channels Tocris Bioscience 1470
      Membrane Transporter/Ion Channel MedChem Express HY-17429
      Membrane Transporter/Ion Channel; MedChem Express HY-17429
      Open Na+ channel blocker that inhibits fast Na+ current in cardiac muscle in a use- and concentration-dependent manner. Orally-active class Ic antiarrhythmic agent. Tocris Bioscience 1470
      Sodium Channel MedChem Express HY-17429
      Sodium Channels Tocris Bioscience 1470
      Voltage-gated Sodium Channels Tocris Bioscience 1470

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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