ChemSpider 2D Image | PNU-200583E | C26H37NO7

PNU-200583E

  • Molecular FormulaC26H37NO7
  • Average mass475.574 Da
  • Monoisotopic mass475.256989 Da
  • ChemSpider ID391966

  • defined stereocentres - 1 of 1 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(2R,3R)-2,3-Dihydroxybernsteinsäure --2-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-methylphenol (1:1) [German] [ACD/IUPAC Name]
(2R,3R)-2,3-dihydroxybutanedioic acid; 2-[(1R)-3-[bis(propan-2-yl)amino]-1-phenylpropyl]-4-methylphenol
(2R,3R)-2,3-Dihydroxysuccinic acid - 2-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-methylphenol (1:1) [ACD/IUPAC Name]
(R)-Tolterodine L-tartrate
124937-52-6 [RN]
2-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]-4-methylphenol 2,3-dihydroxybutanedioate (1:1)
2-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-methyl-phenol tartrate
209747-05-7 [RN]
Acide (2R,3R)-2,3-dihydroxysuccinique - 2-[(1R)-3-(diisopropylamino)-1-phénylpropyl]-4-méthylphénol (1:1) [French] [ACD/IUPAC Name]
Butanedioic acid, 2,3-dihydroxy-, (2R,3R)-, compd. with 2-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-methylphenol (1:1) [ACD/Index Name]
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

5T619TQR3R [DBID]
D01148 [DBID]
Kabi-2234 [DBID]
UN2811 [DBID]
UNII:5T619TQR3R [DBID]
UNII-5T619TQR3R [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Safety:

      Sold for research purposes under agreement from Pfizer Inc. Tocris Bioscience 3761

    • Bio Activity:

      7-TM Receptors Tocris Bioscience 3761
      Acetylcholine (Muscarinic) Receptors Tocris Bioscience 3761
      Acetylcholine Muscarinic Receptors Tocris Bioscience 3761
      GPCR/G protein MedChem Express HY-90010
      GPCR/G protein; Neuronal Signaling; MedChem Express HY-90010
      High affinity muscarinic receptor antagonist (Ki = 3.3 nM). Active at all muscarinic receptor subtypes (M1 - M5); exhibits a greater effect on the bladder than salivary glands in vivo. Tocris Bioscience 3761
      mAChR MedChem Express HY-90010
      Non-selective Muscarinics Tocris Bioscience 3761
      Potent, non-selective muscarinic receptor antagonist Tocris Bioscience 3761
      Tolterodine Tartrate(PNU-200583E; Kabi-2234) is a potent muscarinic receptor antagonists that show selectivity for the urinary bladder over salivary glands in vivo. MedChem Express HY-90010
      Tolterodine Tartrate(PNU-200583E; Kabi-2234) is a potent muscarinic receptor antagonists that show selectivity for the urinary bladder over salivary glands in vivo. ;IC50 Value:;Target: mAChR;In vitro: Carbachol-induced contractions of isolated guinea pig bladder were effectively inhibited by tolterodine (IC50 14 nM) and 5-HM (IC50 5.7 nM). The IC50 values were in the microM range and the antimuscarinic potency of tolterodine was 27, 200 and 370-485 times higher, respectively, than its potency in blocking histamine receptors, alpha-adrenoceptors and calcium channels. The active metabolite, 5-HM, was >900 times less potent at these sites than at bladder muscarinic receptors [1].;In vivo: Tolterodine was extensively metabolized in vivo [2]. In the passive-avoidance test, tolterodine at 1 or 3 mg/kg had no effect on memory; the latency to cross and percentage of animals crossing were comparable to controls. In contrast, scopolamine induced a memory deficit; the latency to cross was MedChem Express HY-90010

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

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