ChemSpider 2D Image | beta-D-Genistin | C21H20O10


  • Molecular FormulaC21H20O10
  • Average mass432.378 Da
  • Monoisotopic mass432.105652 Da
  • ChemSpider ID4444736
  • defined stereocentres - 5 of 5 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

4',5,7-Trihydroxyisoflavone 7-glucoside
4H-1-Benzopyran-4-one, 7- (β-D-glucopyranosyloxy)-5-hydroxy-3-(4-hydroxyphenyl)-
4H-1-Benzopyran-4-one, 7-(β-D-glucopyranosyloxy)-5-hydroxy-3-(4-hydroxyphenyl)-
4H-1-Benzopyran-4-one, 7-(β-D-glucopyranosyloxy)-5-hydroxy-3-(4-hydroxyphenyl)- [ACD/Index Name]
529-59-9 [RN]
5-Hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl β-D-glucopyranoside [ACD/IUPAC Name]
5-Hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl-β-D-glucopyranosid [German] [ACD/IUPAC Name]

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

NSC 5112 [DBID]
48756_FLUKA [DBID]
BRN 0064479 [DBID]
C09126 [DBID]
CHEBI:27514 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Safety:

      P261; P262 Biosynth Q-100603
    • Target Organs:

      Others TargetMol T2882
    • Compound Source:

      Ananas comosus PlantCyc CPD-3421
      Calotropis gigantea PlantCyc CPD-3421
      Capsicum annuum PlantCyc CPD-3421
      Catharanthus roseus PlantCyc CPD-3421
      Cicer arietinum PlantCyc CPD-3421
      Cucumis sativus PlantCyc CPD-3421
      Daucus carota subsp. sativus PlantCyc CPD-3421
      Eucalyptus grandis PlantCyc CPD-3421
      genistein conjugates interconversion PlantCyc CPD-3421
      genistin gentiobioside biosynthesis PlantCyc CPD-3421
      Glycine max PlantCyc CPD-3421
      Linum usitatissimum PlantCyc CPD-3421
      Mimulus guttatus PlantCyc CPD-3421
      Olea europaea var. sylvestris PlantCyc CPD-3421
      Petunia axillaris PlantCyc CPD-3421
      Populus trichocarpa PlantCyc CPD-3421
      Salvia miltiorrhiza PlantCyc CPD-3421
      Solanum melongena PlantCyc CPD-3421
      Solanum pennellii PlantCyc CPD-3421
      Solanum tuberosum PlantCyc CPD-3421
      Triticum aestivum PlantCyc CPD-3421
    • Bio Activity:

      genistin + H2O -> genistein + D-glucopyranose + H+ PlantCyc CPD-3421
      genistin + malonyl-CoA -> malonylgenistin + coenzyme A PlantCyc CPD-3421
      genistin + UDP-alpha-D-glucose -> genistin 7-gentiobioside + UDP + H+ PlantCyc CPD-3421
      Genistin, a natural product, is commonly found in soy and soy products. MedChem Express, HY-N0595
      Genistin, a natural product, is commonly found in soy and soy products. ;IC50 value:;Target:;In vitro: Genistin significantly decreased the vitality of M14 cells, confirming the importance of the 5,7-dihydroxy structure in the a ring in anticarcinogenic effects [1]. The effect of genistin on bone components in the femoral-metaphyseal tissues obtained from elderly female rats was investigated in vitro. The results suggest that genistin has an anabolic effect on bone metabolism in the femoral-metaphyseal tissues of elderly rats [2].;In vivo: Female CD-1 mice were treated on postnatal days 1-5 with oral genistin (6.25, 12.5, 25, or 37.5 mg/kg/day; Oral genistin elicited an estrogenic response in the neonatal uterus, altered ovarian differentiation (i.e., multioocyte follicles), delayed vaginal opening, caused abnormal estrous cycles, decreased fertility, and delayed parturition [3]. MedChem Express HY-N0595
      malonylgenistin + H2O -> malonate + genistin + H+ PlantCyc CPD-3421
      Others MedChem Express HY-N0595
      Others TargetMol T2882
      UDP-alpha-D-glucose + genistein -> genistin + UDP PlantCyc CPD-3421
      UDP-alpha-D-glucose + genistin + genistin + UDP-alpha-D-glucose -> UDP + genistin 7-gentiobioside + UDP + H+ + H+ PlantCyc CPD-3421

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.6±0.1 g/cm3
Boiling Point: 788.9±60.0 °C at 760 mmHg
Vapour Pressure: 0.0±2.9 mmHg at 25°C
Enthalpy of Vaporization: 120.4±3.0 kJ/mol
Flash Point: 280.7±26.4 °C
Index of Refraction: 1.717
Molar Refractivity: 103.7±0.3 cm3
#H bond acceptors: 10
#H bond donors: 6
#Freely Rotating Bonds: 4
#Rule of 5 Violations: 2
ACD/LogP: 0.79
ACD/LogD (pH 5.5): 0.56
ACD/BCF (pH 5.5): 1.49
ACD/KOC (pH 5.5): 43.57
ACD/LogD (pH 7.4): -0.64
ACD/BCF (pH 7.4): 1.00
ACD/KOC (pH 7.4): 2.77
Polar Surface Area: 166 Å2
Polarizability: 41.1±0.5 10-24cm3
Surface Tension: 91.4±3.0 dyne/cm
Molar Volume: 263.2±3.0 cm3

Predicted data is generated using the US Environmental Protection Agency’s EPISuite™

 Log Octanol-Water Partition Coef (SRC):
    Log Kow (KOWWIN v1.67 estimate) =  0.83

 Boiling Pt, Melting Pt, Vapor Pressure Estimations (MPBPWIN v1.42):
    Boiling Pt (deg C):  680.21  (Adapted Stein & Brown method)
    Melting Pt (deg C):  296.78  (Mean or Weighted MP)
    VP(mm Hg,25 deg C):  1.43E-020  (Modified Grain method)
    Subcooled liquid VP: 1.53E-017 mm Hg (25 deg C, Mod-Grain method)

 Water Solubility Estimate from Log Kow (WSKOW v1.41):
    Water Solubility at 25 deg C (mg/L):  1417
       log Kow used: 0.83 (estimated)
       no-melting pt equation used

 Water Sol Estimate from Fragments:
    Wat Sol (v1.01 est) =  1e+006 mg/L

 ECOSAR Class Program (ECOSAR v0.99h):
    Class(es) found:
       Vinyl/Allyl Ketones
       Vinyl/Allyl Ethers

 Henrys Law Constant (25 deg C) [HENRYWIN v3.10]:
   Bond Method :   1.05E-025  atm-m3/mole
   Group Method:   Incomplete
 Henrys LC [VP/WSol estimate using EPI values]:  5.742E-024 atm-m3/mole

 Log Octanol-Air Partition Coefficient (25 deg C) [KOAWIN v1.10]:
  Log Kow used:  0.83  (KowWin est)
  Log Kaw used:  -23.367  (HenryWin est)
      Log Koa (KOAWIN v1.10 estimate):  24.197
      Log Koa (experimental database):  None

 Probability of Rapid Biodegradation (BIOWIN v4.10):
   Biowin1 (Linear Model)         :   1.3315
   Biowin2 (Non-Linear Model)     :   0.9775
 Expert Survey Biodegradation Results:
   Biowin3 (Ultimate Survey Model):   2.8489  (weeks       )
   Biowin4 (Primary Survey Model) :   3.9434  (days        )
 MITI Biodegradation Probability:
   Biowin5 (MITI Linear Model)    :   0.8756
   Biowin6 (MITI Non-Linear Model):   0.2573
 Anaerobic Biodegradation Probability:
   Biowin7 (Anaerobic Linear Model):  0.8126
 Ready Biodegradability Prediction:   YES

Hydrocarbon Biodegradation (BioHCwin v1.01):
    Structure incompatible with current estimation method!

 Sorption to aerosols (25 Dec C)[AEROWIN v1.00]:
  Vapor pressure (liquid/subcooled):  2.04E-015 Pa (1.53E-017 mm Hg)
  Log Koa (Koawin est  ): 24.197
   Kp (particle/gas partition coef. (m3/ug)):
       Mackay model           :  1.47E+009 
       Octanol/air (Koa) model:  3.86E+011 
   Fraction sorbed to airborne particulates (phi):
       Junge-Pankow model     :  1 
       Mackay model           :  1 
       Octanol/air (Koa) model:  1 

 Atmospheric Oxidation (25 deg C) [AopWin v1.92]:
   Hydroxyl Radicals Reaction:
      OVERALL OH Rate Constant = 292.7308 E-12 cm3/molecule-sec
      Half-Life =     0.037 Days (12-hr day; 1.5E6 OH/cm3)
      Half-Life =    26.308 Min
   Ozone Reaction:
      OVERALL Ozone Rate Constant =    10.500000 E-17 cm3/molecule-sec
      Half-Life =     0.109 Days (at 7E11 mol/cm3)
      Half-Life =      2.619 Hrs
   Reaction With Nitrate Radicals May Be Important!
   Fraction sorbed to airborne particulates (phi): 1 (Junge,Mackay)
    Note: the sorbed fraction may be resistant to atmospheric oxidation

 Soil Adsorption Coefficient (PCKOCWIN v1.66):
      Koc    :  45.01
      Log Koc:  1.653 

 Aqueous Base/Acid-Catalyzed Hydrolysis (25 deg C) [HYDROWIN v1.67]:
    Rate constants can NOT be estimated for this structure!

 Bioaccumulation Estimates from Log Kow (BCFWIN v2.17):
   Log BCF from regression-based method = 0.500 (BCF = 3.162)
       log Kow used: 0.83 (estimated)

 Volatilization from Water:
    Henry LC:  1.05E-025 atm-m3/mole  (estimated by Bond SAR Method)
    Half-Life from Model River: 1.159E+022  hours   (4.831E+020 days)
    Half-Life from Model Lake : 1.265E+023  hours   (5.27E+021 days)

 Removal In Wastewater Treatment:
    Total removal:               1.87  percent
    Total biodegradation:        0.09  percent
    Total sludge adsorption:     1.78  percent
    Total to Air:                0.00  percent
      (using 10000 hr Bio P,A,S)

 Level III Fugacity Model:
           Mass Amount    Half-Life    Emissions
            (percent)        (hr)       (kg/hr)
   Air       3.08e-007       0.657        1000       
   Water     35.8            360          1000       
   Soil      64.1            720          1000       
   Sediment  0.0697          3.24e+003    0          
     Persistence Time: 601 hr


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