ChemSpider 2D Image | Eprosartan mesylate | C24H28N2O7S2

Eprosartan mesylate

  • Molecular FormulaC24H28N2O7S2
  • Average mass520.618 Da
  • Monoisotopic mass520.133789 Da
  • ChemSpider ID4445620

  • Double-bond stereo - Double-bond stereo

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

144143-96-4 [RN]
2-Thiophenepropanoic acid, α-[[2-butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-yl]methylene]-, (αE)-, methanesulfonate (1:1) [ACD/Index Name]
4-({2-Butyl-5-[(1E)-2-carboxy-3-(2-thienyl)-1-propen-1-yl]-1H-imidazol-1-yl}methyl)benzoesäure -methansulfonsäure (1:1) [German] [ACD/IUPAC Name]
4-({2-Butyl-5-[(1E)-2-carboxy-3-(2-thienyl)-1-propen-1-yl]-1H-imidazol-1-yl}methyl)benzoic acid methanesulfonate (1:1) [ACD/IUPAC Name]
4-({2-butyl-5-[(1E)-2-carboxy-3-(thiophen-2-yl)prop-1-en-1-yl]-1H-imidazol-1-yl}methyl)benzoic acid methanesulfonate (1:1)
4-({2-butyl-5-[(1E)-2-carboxy-3-thiophen-2-ylprop-1-en-1-yl]-1H-imidazol-1-yl}methyl)benzoic acid methanesulfonate
4-({2-Butyl-5-[(1E)-2-carboxy-3-thiophen-2-ylprop-1-en-1-yl]-1H-imidazol-1-yl}methyl)benzolcarbonsäure-methansulfonsäure(1:1)
8N2L1NX8S3
Acide 4-({2-butyl-5-[(1E)-2-carboxy-3-(2-thiényl)-1-propén-1-yl]-1H-imidazol-1-yl}méthyl)benzoïque - acide méthanesulfonique (1:1) [French] [ACD/IUPAC Name]
acide 4-({2-butyl-5-[(1E)-2-carboxy-3-thiophén-2-ylprop-1-én-1-yl]-1H-imidazol-1-yl}méthyl)benzoïque - acide méthanesulfonique (1:1)
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

D02082 [DBID]
LS-173203 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      RAAS inhibitor; ACE inhibitor TargetMol T2531

    • Bio Activity:

      7-TM Receptors Tocris Bioscience 4696
      Angiogenesis;Endocrinology/ Hormones TargetMol T2531
      Angiotensin Receptor MedChem Express HY-15834A
      Angiotensin Receptors Tocris Bioscience 4696
      AT1 receptor TargetMol T2531
      Eprosartan is a nonpeptide angiotensin II receptor antagonist with IC50 of 9.2 and 3.9 nM in rat and human adrenal cortical membranes, respectively. MedChem Express , HY-15834A
      Eprosartan is a nonpeptide angiotensin II receptor antagonist with IC50 of 9.2 and 3.9 nM in rat and human adrenal cortical membranes, respectively. ;IC50 Value: 9.2 nM(in rat adrenal cortical membranes); 3.9 nM(in human adrenal cortical membranes);Target: Angiotensin Receptor Type-1(AT1);In vitro: Eprosartan mesylate, is one of the highly selective, orally active, non-peptide angiotensin-II-receptor antagonists [1]. In rat and human adrenal cortical membranes, Eprosartan displaced specifically bound [125I]AII with IC50 of 9.2 and 3.9 nM, respectively. Eprosartan also inhibited [125I]AII binding to human liver membranes (IC50 = 1.7 nM) and to rat mesenteric artery membranes (IC50 = 1.5 nM). In rabbit aortic smooth muscle cells, Eprosartan caused a concentration-dependent inhibition of AII-induced increases in intracellular Ca++ levels. In rabbit aortic rings [2].;In vivo: Administration of Eprosartan (3-10 mg/kg) intraduodenally or intragastrically to conscious normotensive rats MedChem Express HY-15834A
      GPCR/G protein MedChem Express HY-15834A
      GPCR/G protein; MedChem Express HY-15834A
      Peptide Receptors Tocris Bioscience 4696
      Potent and selective AT1 receptor antagonist Tocris Bioscience 4696
      Potent angiotensin II receptor 1 (AT1) antagonist (IC50 values are 1.5, 1.7, 3.9 and 9.2 nM at rat mesenteric artery, human liver membrane, human adrenal cortical membrne and rat adrenal cortical memb rane respectively). Displays no effect on vasopressin or CGRP binding, or angiotensin-converting enzyme (ACE) activity. Inhibits the angiotensin II-induced pressor response in normotensive rats. Tocris Bioscience 4696
      Potent angiotensin II receptor 1 (AT1) antagonist (IC50 values are 1.5, 1.7, 3.9 and 9.2 nM at rat mesenteric artery, human liver membrane, human adrenal cortical membrne and rat adrenal cortical membrane respectively). Displays no effect on vasopressin or CGRP binding, or angiotensin-converting enzyme (ACE) activity. Inhibits the angiotensin II-induced pressor response in normotensive rats. Tocris Bioscience 4696

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

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